30Mar 2017

Clinical profile of Central Nervous System Tuberculosis in Kanniya kumari medical college.

  • Assisstant Professor of Medicine, Kanniyakumari Govt. Medical College.
  • Professor of Medicine, Kanniyakumari Govt. Medical College.
  • Postgraduate in General Medicine, Kanniyakumari Govt. Medical College.
Crossref Cited-by Linking logo
  • Abstract
  • References
  • Cite This Article as
  • Corresponding Author

Background: Tuberculosis of the central nervous system is an important cause of morbidity and mortality. Once a disease mainly of childhood, it is now seen at any age and is equally frequent in adults. They may present as Meningitis, Tuberculoma, Potts Paraplegia, Intraspinal Granuloma or Arachnoiditis. This study was conducted to analyse various clinical presentations of CNS tuberculosis and their sequelae. Methods :An observational study was conducted in 30 patients admitted in Kanniyakumari Government Medical College from Jan 2016 to December 2016 with CNS manifestations of Tuberculosis. Computed tomography(CT), electroencephalography (EEG) and clinical findings were taken. Results: In the present study, the most common CNS presentation was Tuberculous Meningitis followed by Tuberculoma. Common age group being between 15-19 yrs. Aseptic meningitis had a good prognosis compared to Obstructive Hydrocephalus which had a bad prognosis. In this series, complete recovery was 66.6%, mortality was 13.4% and Sequelae in 20%.Conclusion: CNS tuberculosis is being reported more often nowadays due to its awareness and improved diagnostic modalities. Resistance to drugs has added a new challenge. Morbidity and mortality can be reduced by a great extent with early recognition and timely treatment

  1. Rieder H L, Snider D E, Jr, Cauthen G M. Extrapulmonary tuberculosis in the United States.Am Rev Respir Dis.?1990;141:347?351
  2. CDC, author.Extrapulmonary tuberculosis cases and percentages by site of disease: reporting areas, 2005.?Atlanta, GA: Centers for Disease Control and Prevention; 2005
  3. Lu T H, Huang R M, Chang T D, Tsao S M, Wu T C. Tuberculosis mortality trends in Taiwan: a resurgence of non-respiratory tuberculosis.Int J Tuberc Lung Dis.?2005;9:105?110
  4. Cherian A, Thomas SV. Central nervous system tuberculosis.African Health Sciences: 2011 march; 11(1) :116-127
  5. Berger?JR?(1994)?Tuberculous meningitis.?Curr Opin Neurol?7:191?200
  6. Udani, P.M., Parekh, U.C., Dastur, D.K.Neurological and related syndromes in CNS tuberculosis. Clinical features and pathogenesis.?J Neurol Sci.?1971;14:341
  7. Tandon PH, Bhargava S.Effect of Medical Treatment in intracranial tuberculoma: a CT study; Tubercle 1985; 66:85
  8. Dastur DK, Udani PM. The pathology and pathogenesis of tuberculous encephalopathy.Acta Neuropathol.?1966 Jul 7;6(4):311?326.
  9. Lincoln, E.M., Sordillo, S.V.R., Davis, P.A.Tuberculous meningitis in children. A review of 167 untreated and 74 treated patients with special reference to early diagnosis.?J Pediatr.?1960;57:80
  10. British Medical Journal No.7176, 9 Jan 1999-C Ettle and MH Wilcox
  11. Saeed S.H., Spinal Tuberculosis; A Review. Indep Rev Oct-Dec 2013;15(10-12): 481-490.

[Bhamini Prakash, Christopher Nesamony, Suhas Raj Sivakumar, Thirukumareswaran Vijayan and Sindhu Neelakandan. (2017); Clinical profile of Central Nervous System Tuberculosis in Kanniya kumari medical college. Int. J. of Adv. Res. 5 (Mar). 2389-2395] (ISSN 2320-5407). www.journalijar.com

Dr.Bhamini Prakash
Assisstant Professor of Medicine

DOI:

Article DOI: 10.21474/IJAR01/3768      
DOI URL: http://dx.doi.org/10.21474/IJAR01/3768

Download Full Paper

Download PDF No. of Downloads: 37 | No. of Views: 153