22Apr 2017

A KINETIC STUDY OF RUBAZOIC ACID FORMATION DERIVED FROM 4-AMINO-1(4-SULPHOPHENYL) 3-METHYL-2-PYRAZOLIN-5-ONE.

  • Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
  • Department of Chemistry, University of Management and Technology Lahore-54000, Pakistan.
  • Department of Chemistry, GC University, Kachehry Road, Lahore 54000, Pakistan.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

A kinetic study based on spectrophotometric and titrimetric techniques has been carried out for the formation of Rubazoic acid (4E)-4-[(5-hydroxy-3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)imino]-5-methyl-2-phenyl-2,4 dihydro-3H-pyrazol-3-one from 4-amino-1(4-sulphophenyl) 3-methyl-2-pyrazolin-5-one. Physicochemical factors like effect of time, pH, aeration and temperature on its formation have been investigated in detail. Elemental analysis, UV-Visible spectral study, FTIR spectral study, 1H-NMR and 13C-NMR spectral study was employed for understanding the reaction path way for the formation of rubazoic acid.


  1. Kala H (1963): Die Pharmazie, On the photometric determination of nitrogen in organic compounds by the rubazonic acid method. 18-21 29.
  2. AB Ballot, C Steendijk (1965): Clinica Chimica Acta, Ammonia determination in a trichloroacetic acid blood filtrate after microdiffusion with the aid of the rubazonic acid reaction 55-62 12(1).
  3. SE Sheppard, RC Houck (1940): Photographic antihalation layer, US, 2203659.
  4. PJ Wrigth, (1978): Quaternary ammonium polymers and photographic materials containing sameUS, 4108802.
  5. L Knorr, (1887): Justus Liebigs Ann. Chem, Synthetische Versuche mit dem Acetessigester 238-243 137.
  6. T Curtius, (1992) J P rakt Chem, Chemistry of Heterocyclic Compounds, Pyrazolones, Pyrazolidones, and Derivatives, 85, 37.
  7. ED Bergmann, D Ginsburg, R Pappo, (2011): Organic Reactions, The Michael Reaction, 179?556 10(3).
  8. A Heiduschka, O Rothacker, (1911): J Fur Pr Chem, synthesis of 1-phenyl-3-methyl-4-amino-fi-pyrazolone, 534-537 84.
  9. W Wislicnus, H Goz, (1911): Conversion of the Nitro- into the Keto-group, Ber, 3491-3496 44.
  10. A Wahl, M Doll, (1913): Reactions of @-Diketonic Esters, Soc. Chim. Franc, 468-475 13.
  11. E Votocek, O Wichterle, (1935): Collection Czechoslov Commun, 4-(5-Hydroxy-4-pyrazolylimino)-2-pyrazolin-5-one und ihre Metallchelate, Synthese von 4-(5-Hydroxy-4-pyrazolylimino)-2-pyrazolin-5-onen (Rubazons?uren) und strukturanalogen Verbindungen, 388-393 7.
  12. M Freri, (1936): Gaz Chim Ital, Chemistry of Heterocyclic Compounds: Pyrazolones, Pyrazolidones, and Derivatives, 1498-1502 23.
  13. AB Nies, BNJ Brook, (1947): Diazo compounds of the pyrazolone. US, 2420791.
  14. H Gysling, G Schwarzenbach, (1949): Hel Chim Acta, Spectrophotometric Determination of Magnesium, Calcium, Strontium and Barium Present in Pairs by Use of Tetramethylmurexide 1484-1488, 32.
  15. GF Duffin, JD Kendall, (1955); J Chem Soc, Chemistry of Heterocyclic Compounds: Triazoles 1,2,4, 3669-3673, 2.
  16. G Michaelis, F Wrede, (1907): Ann. Reactive intermediates in the photochemistry of 4-diazo-2-pyrazolin-5-ones, 352-356, 152.
  17. G Westoo, (1965): Acta Chem Scand, On the Metabolism of Tartrazine in the Rat. 1309-1309, 19.
  18. CS Rondestvedt, PK Chang, (1955): J Am Chem Soc, Pechmann Pyrazole Synthesis. 6532-6536, 77.
  19. HE Fierz-David, L Blangey, (1949): Interscience Publishers Inc London Fundamental Process of Dye Chemistry, 1-253 2.

[Ghulam Hussain, Shakeel Ahmad Khan, Waqar Ahmad, Makshoof Athar and Rashid Saleem. (2017); A KINETIC STUDY OF RUBAZOIC ACID FORMATION DERIVED FROM 4-AMINO-1(4-SULPHOPHENYL) 3-METHYL-2-PYRAZOLIN-5-ONE. Int. J. of Adv. Res. 5 (4). 234-241] (ISSN 2320-5407). www.journalijar.com


Shakeel Ahmad Khan
Department of chemistry, University of Management and Technology Lahore-54000, Pakistan

DOI:


Article DOI: 10.21474/IJAR01/3800       DOI URL: http://dx.doi.org/10.21474/IJAR01/3800


Share this article