20Jul 2017

STUDY OF COMPARISON BETWEEN AUTONOMIC DYSFUNCTION AND DYSLIPIDEMIA IN HEALTHY POSTMENOPAUSAL WOMEN.

  • Consultant physician-khammam.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background: Obesity, physical inactivity, and altered estrogen levels play an important role in contributing to disease risk profile and autonomic dysfunction in healthy postmenopausal women. This study was conducted to test the correlation between autonomic dysfunction and dyslipidemia in healthy postmenopausal women. Materials and Methods: This study was carried out on sixty healthy postmenopausal women before the age of 65 years, without any gross systemic disease. The following five autonomic functional tests were performed on the study group: heart rate response to deep breathing, heart rate response to Valsalva maneuver, heart rate response to standing up from supine position, blood pressure response to sustained hand grip, and blood pressure response to standing up from supine position. Fasting lipid profile of the study group was tested. Results and Conclusion: In the present study, autonomic dysfunction was found in 67% of healthy postmenopausal women. Among the sixty female healthy postmenopausal women included in the study, 68% were found to have dyslipidemia. In our study, there is a statistically significant correlation between autonomic dysfunction and dyslipidemia in healthy postmenopausal women. In these healthy postmenopausal women with increased serum cholesterol, serum low-density lipoprotein, and serum triglycerides, there was autonomic dysfunction which is statistically significant. There is no statistical significance on comparing serum high-density lipoprotein cholesterol with autonomic dysfunction in healthy postmenopausal women.


  1. Report of a WHO Scientific Group. Research on the menopause in the 1990s. World Health Organ Tech Rep Ser 1996;866:1‑107.
  2. Kalantaridou SN, Naka KK, Bechlioulis A, Makrigiannakis A, Michalis L, Chrousos GP, et al. Premature ovarian failure, endothelial dysfunction and estrogen-progesterone replacement Trends EndocrinolMetab 2006;17:101-9.
  3. Naher LA, Begum N, Begum S, Ferdousi S, Ali T, Sultana M, Ali ML. The relationships of parasympathetic nerve function parameters with endogenous estrogen level in postmenopausal women. The ORION Medical Journal 2009;32:654-6.
  4. Burger?HG, Dudley?EC, Hopper?JL, Shelley?JM, Green?A, Smith?A, et?al. The endocrinology of the menopausal transition: A cross‑sectional study of a population‑based sample. J?ClinEndocrinolMetab 1995;80:3537‑45.
  5. Tsuji?H, Larson?MG, Venditti FJ Jr., Manders?ES, Evans?JC, Feldman?CL, et?al. Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 1996;94:2850‑5.
  6. Ankleseria BS, Soneji RM: Risk-Benefit balance in man of menopause. In: Purandare CN, Khadilkar SS, editors. Menopause: Current Concepts; FOGSI. 1st Jaypee brothers; 2004. p. 201-2.
  7. Pal GK, Pal P. Autonomic function tests. Textbook of Practical Physiology. 2nd Orient BlackSwan/ Universities Press; 2005. p. 296-304.
  8. Ewing?DJ, Clarke?BF. Diagnosis and management of diabetic autonomic neuropathy. Br Med J?(Clin Res Ed) 1982;285:916‑8.
  9. Torsvik?M, H?ggblom A, Eide?GE, Schmutzhard?E, Vetvik?K, Winkler?AS. Cardiovascular autonomic function tests in an African population. BMC EndocrDisord 2008;8:19.
  10. Park?K. Park?s Textbook of Preventive and Social Medicine. Jabalpur, India: Bhanot; 2009. p.?315.
  11. Kushner RF. Evaluation and management of obesity. Harrison?sPrinciples of Internal Medicine. 18th Vol. 2. Ch. The NewyorkMcGrawhill Companies Inc; 2012. p. 3158-61. [742-56].
  12. Kimura?T, Matsumoto?T, Akiyoshi?M, Owa?Y, Miyasaka?N, Aso?T, et?al. Body fat and blood lipids in postmenopausal women are related to resting autonomic nervous system activity. Eur J ApplPhysiol 2006;97:542‑7.
  13. Virtanen?I, Polo‑Kantola?P, Erkkola?R, Polo?O, Ekholm?E. agement Climacteric vasomotor symptoms do not imply autonomic dysfunction. Br J ObstetGynaecol 1999;106:155‑64.
  14. Saeki?Y, Atogami?F, Hiraishi?M, Furuta?N, Yoshizawa?T. Impairment of autonomic function induced by posture change in postmenopausal women. J?Womens Health 1998;7:575‑82.
  15. Posner?BM, Cupples?LA, Miller?DR, Cobb?JL, Lutz?KJ, D?Agostino?RB. Diet, menopause, and serum cholesterol levels in women: the Framingham Study. Am Heart J 1993;125(2 Pt 1):483‑9.
  16. Danev?S, Nikolova?R, Kerekovska?M, Svetoslavov?S. Relationship between heart rate variability and hypercholesterolaemia. Cent Eur J Public Health 1997;5:143‑6.
  17. Doncheva?NI, Nikolova?RI, Danev?SG. Overweight, dyslipoproteinemia, and heart rate variability measures. Folia Med?(Plovdiv) 2003;45:8‑12.
  18. Chaudhuri?A, Borade?NG, Hazra?SK. A?study of heart rate variablity tests and lipid profile in postmenopausal women. J?Indian Med Assoc 2012;110:228, 230‑2.
  19. Rosano?GM, Patrizi?R, Leonardo?F, Ponikowski?P, Collins?P, Sarrel?PM, et?al. Effect of estrogen replacement therapy on heart rate variability and heart rate in healthy postmenopausal women. Am J Cardiol 1997;80:815‑7.

[Kavyachand yalamudi. (2017); STUDY OF COMPARISON BETWEEN AUTONOMIC DYSFUNCTION AND DYSLIPIDEMIA IN HEALTHY POSTMENOPAUSAL WOMEN. Int. J. of Adv. Res. 5 (Jul). 968-980] (ISSN 2320-5407). www.journalijar.com


DR.KAVYACHAND YALAMUDI
CONSULTANT PHYSICIAN,DEPARTMENT OF GENERAL MEDICINE,NEWLIFE HOSPITALS-KHAMMAM-TELANGANA STATE-507001-INDIA

DOI:


Article DOI: 10.21474/IJAR01/4805      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4805