10Oct 2017

SOME HORMONAL CONTRACEPTIVES, HORMONE-RELATED REPRODUCTIVE BREAST CANCER RISK FACTORS AMONG WOMEN IN PORT HARCOURT: A CASE-CONTROL STUDY.

  • MPH Student and Correspondence Author, Department of Preventive and Social Medicine, of the University of Port Harcourt, Port Harcourt, Nigeria.
  • Lecturers of the Department of Preventive and Social Medicine, of the University of Port Harcourt, Port Harcourt, Nigeria.
  • General Surgeon of the Department of Surgery, University of Port Harcourt, Port Harcourt, Nigeria.
  • General Surgeon of the Department of Surgery, University of Port Harcourt, Port Harcourt, Nigeria.
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Aim: To determine the association between hormonal contraceptives / other hormonal-related reproductive risk factors and breast cancer among women in Port Harcourt. Background: Despite the known benefits of hormonal contraceptive agents and other well established non-contraceptive benefits, they have been associated with risk of breast cancer among women. In addition to hormonal agents, some other factors have been associated with the risk of breast cancer. Materials and Methods: The study was carried out among patients with clinically and histologically confirmed breast cancer (as cases) and patients without any known cancer (as controls) in the out-patient clinics and wards of the public (and some private) tertiary hospitals in Port Harcourt. All histologically confirmed breast cancer patients were recruited for the study and the controls were individually matched based on age with a matching ratio of 1:1. Results: The mean age for the case control study was 44.67?13.41 (cases) and 46.11?13.76 respectively. The odds of developing breast cancer among the women using oral contraceptive pills was similar to that of women who were not using oral contraceptive pills. The odds of developing breast cancer among the women using injectable hormonal agents was 1.26 times higher among women with breast cancer (OR = 1.26, 95% CI=0.74-2.16), although, the relationship was not significant (P>0.05). Those that were 18 years old at first pregnancy were less likely to develop breast cancer compared to women greater than 18 years old at first pregnancy, the relationship was significant. Conclusion: Injectable contraceptives in this study were associated with higher odds of developing breast cancer among cases than controls though the relationship was not significant. Pregnancy before 18 years of age reduces the odds of breast cancer significantly.


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[Ijah R. F, Adeniji F. O, Mezie-Okoye M. M. and Dodiyi-Manual A. (2017); SOME HORMONAL CONTRACEPTIVES, HORMONE-RELATED REPRODUCTIVE BREAST CANCER RISK FACTORS AMONG WOMEN IN PORT HARCOURT: A CASE-CONTROL STUDY. Int. J. of Adv. Res. 5 (10). 15-24] (ISSN 2320-5407). www.journalijar.com


Ijah1, R.F.*,
MPH Student and Correspondence Author, Department of Preventive and Social Medicine, of the University of Port Harcourt, Port Harcourt, Nigeria

DOI:


Article DOI: 10.21474/IJAR01/5502       DOI URL: http://dx.doi.org/10.21474/IJAR01/5502


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