18Sep 2017

REVIEW ON THE ROLE OF OXIDATIVE STRESS IN FEMALE INFERTILITY.

  • Department of Biochemistry, Faculty of Natural and Applied Sciences, Umaru Musa Yar?adua University Katsina, Nigeria.
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Oxidative stress result from imbalance between free radicals formation and antioxidant defence in the body. It is a process that influences entire reproductive cycle of a woman from gametogenesis, fertilization, pregnancy and embryo development. Both ROS and RNS act as signal molecules in physiological and pathological processes of female reproductive tract. Several in vitro and in vivo studies on reproductive organs lead to observation that free radicals attack and oxidize membrane macromolecules which when accumulate, amplify tissue damage and cell death. Structural identification and characterization of compounds of plant origin capable of either boosting the endogenous antioxidants or scavenging these radicals accumulating in reproductive cells is needed to minimize the dangerous effects and explore the relationship between oxidative stress and female infertility. Nowadays, scientists are on investigations on the role of oxidative stress on the current events of infertility and development of therapeutic approaches for limiting infertility aggravated by oxidative stress. There is strong evidence of increased free radical generation in pregnancy which leads to oxidative stress. This article reviews the role of ROS and RNS in both physiological and pathological processes leading to female infertility.

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[Salahuddeen Ya?u and Zainab Suleiman Abubakar. (2017); REVIEW ON THE ROLE OF OXIDATIVE STRESS IN FEMALE INFERTILITY. Int. J. of Adv. Res. 5 (Sep). 539-543] (ISSN 2320-5407). www.journalijar.com

Salahuddeen Ya\'u
Department of Biochemistry, Faculty of Natural and Applied Science, Umaru Musa Yar'adua University, Katsina, Nigeria

DOI:

Article DOI: 10.21474/IJAR01/5358      
DOI URL: http://dx.doi.org/10.21474/IJAR01/5358

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