Vol. 5 (09) pp. 87-92 DOI: 10.21474/IJAR01/5304

SYNTHESIS AND CHARACTERIZATION OF A NEW BIOACTIVE MANNICH BASE MORPHOLINO METHYL MALEIC HYDRAZIDE (MMMH).

, and
  • Department of chemistry,A.V.C College(Autonomous),Mannampandal,Mayiladuthurai, Tamilnadu, India.
  • Department of chemistry ,Government Arts College for Men (Autonomous), Nandanam, Chennai-35,Tamilnadu,India.
44 Downloads 162 Views
Crossref

Download Full Paper (PDF)

Abstract

In this study a new N-Mannich base Morpholino Methyl Maleic Hydrazide (MMMH) was synthesized by introducing morpholinomethyl moiety in place of active hydrogen atom attached to nitrogen of maleichydrazide through Mannich reaction.The newly synthesized mannich base structure was characterized by elemental analysis,IR,UV-Visible,NMR and Mass spectra.Based on the spectral and analytical data the structure of the N-Mannich base was confirmed.

Keywords

Article Analytics

References

  1. Kamiya et al,Natl.Inst.Hug.Scis.,Tokyo,Japan,Yakugaku Zasshi,1966,86,1099.
  2. Hellmann,Heinrich,Losehmann,Isolde,Univ.TubingenGermany,Chem.Ber.,1956,89,594.
  3. Lan,P.,Chen,W.N.,Xiao,G.K.,Sun,P.H.and Chen,W.M.,Bioorg.Med.Chem.Lett.,2010,20,6064.
  4. Raparti,V.,Chitre,T.,Bothra,K.,Kumar,V.,Dangre,S.,Kanchane,C.,Gore,S.andDeshmane,B.,Eur.J.Med.Chem.,2009,44,3954.
  5. Wang,L.J.,Li,W.W.,Yang,S.Y and Yang,L.,Acta Cryst.,2012,E68,01235.
  6. Nakamoto,K. Infrared Spectra of Inorganic and Coordination Compounds, Wiley Interscience: New York; 1970.
  7. Rathakrishnan,S.,AbdulJameel,A.,Syed Ali Padusha,M.,Int.J.Scientific and Research Publications,2014,Vol.4,(7),pp.1-8.
  8. Sethi,R.,Arora,S.,Jain,N.,Jain,S.,J.Pharmaceutical Technology Research and Management,2015,Vol.3,(2),pp.97-111.
  9. SumanBala,NehaSharma,AnuKajal,SunilKamboj and Vipin Saini,Int.J.Med.Chem,2014,pp.1-15.
  10. Barakat,Mohamed S. El-Attar ,Int.J.Advances in Pharmacy,Biology and Chemistry,2015,Vol.4(2).pp.439-442.

How to Cite This Article

P. R. Santhi, G. Selvanathan and G. Poongothai. (2017); SYNTHESIS AND CHARACTERIZATION OF A NEW BIOACTIVE MANNICH BASE MORPHOLINO METHYL MALEIC HYDRAZIDE (MMMH)., Int. J. of Adv. Res., 5 (09), 87-92, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/5304

Corresponding Author

P.R.Santhi
Department of chemistry,A.V.CCollege(Autonomous),Mannampandal,Mayiladuthurai, Tamilnadu, India.
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.