Assessment of in vitro anti-Trichomonas vaginalis activity of deer musk

Abstract: Trichomoniasis is a sexually transmitted disease afflicting many women worldwide. The disease is usually not life-threatening, but has been associated with the development many serious health problems. The development of resistant Trichomonas vaginalis strains necessitates the development of other nontraditional medications. Studies on deer musk showed its anti-bacterial and anti-fungal affects. This study was carried out to evaluate in vitro effects of different concentrations of musk 10, 15, 20, 25 and 30% (vol/vol) for 24, 48, 72and 96 hours at 37 °C on multiplication, viability and motility of Trichomonas vaginalis also morphological changes using scanning and transmission electron microscopy were reported and optical density of treated cultures were assayed. The minimal inhibitory concentrations of musk were 10% at 96h, 15% at 72h, 20% and 25% at 48h and 30% at 24h. The calibration curve of musk studied concentrations was found to be linear (R2 = 0.942) indicating large positive association between the concentration of musk and the optical density of the culture.Musk is a safe natural product having the privilege of being anti Trichomonas vaginalis as well as antifungal and antibacterial properties so it provides a promising source for new drugs development.

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[Abeer Fathy Badawy, Noha Abdelfattah Elleboudy, Hend Mohamed Hussein (2014); Assessment of in vitro anti-Trichomonas vaginalis activity of deer musk Int. J. of Adv. Res. 2 (8). 0] (ISSN 2320-5407). www.journalijar.com

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