01May 2019

TO STUDY THE EFFECT OF KANTAKARYAVALEHYA ON EOSINOPHIL CATIONIC PROTEIN (ECP) LEVELS IN CHILDHOOD ASTHMA.

  • Principal Investigator & Corresponding author, Assistant Professor, Dept. of PG studies in Roganidana, JSS Ayurveda Medical College, Mysuru.
  • Co-investigator, Dean - Academics, JSS Ayurveda Medical College, Mysuru.
  • Co-investigator, Assistant professor, dept. of pg studies in roganidana, JSS Ayurveda Medical College, Mysuru.
  • Dept of health & nutrition, Doman International Institute, Pennsylvania, USA.
  • Professor, Dept. of Biochemistry, JSSMedical College, JSSAHER,Mysuru.
  • Ph D Scholar, CEMR Laboratory, Dept. of Biochemistry, JSS Medical College, JSSAHER, Mysuru.
  • Principal, Govt. Ayurveda Medical College, Bengaluru.
  • Professor & HOD, Dept. of Kayachikitsa, Govt. Ayurveda Medical College, Mysuru.
Crossref Cited-by Linking logo
  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Background:Childhood asthma is one among the most common causes for hospital visits in India. It has its impact on the socio-economic and psychological factors of the sufferers. School absenteeism in children due to childhood asthma is not uncommon. Ayurveda line of treatment can be of immense help in preventing and providing succor to patients. This study was intended to assess the efficacy of Kantakaryavalehya clinically and on ECP levels in Childhood asthma. Objectives: This research study had two objectives 1. To assess the efficacy of Kantakaryavalehya on Childhood asthma clinically 2. To assess the efficacy of Kantakaryavalehya on Eosinophil Cationic Protein levels in Childhood asthma. Methods: 20 childhood asthmatics were selected for the study. They were administered with the trial drug Kantakaryavalehya for 90 days with assessment at interval of every 30 days. Blood was drawn before and after the study period to evaluate the serum ECP levels. GINA guidelines 2016 was followed for clinical assessment of Asthma. Results:In both clinical and objective evaluations, results were encouraging. Clinical assessment of level of asthma control was found statistically marginally significant (p-0.059), improvement in terms of PEF rate was highly significant (p=0.03). Assessment of ECP levels in serum and comparison before and after treatment showed marginally statistically significant results (p-0.07). Though the effect of Kantakaryavalehya on ECP levels was marginally significant, it was strikingly evident in terms of clinical improvement and with respect to PEFR. Conclusion:Kantakaryavalehya may be used as a drug of choice in the management of Childhood asthma.

  1. OP. Ghai Essential Pediatrics.6th Edition Revised and Enlarged, . CBS publishers. 2005:354-65.
  2. Munjal YP. API Textbook of Medicine. 9th Edition, editor: The Association of Physicians of India; 2012. Section 23, Pulmonary Medicine; 2012.
  3. Joseph-Bowen J, de Klerk N, Holt PG, Sly PD. Relationship of asthma, atopy, and bronchial responsiveness to serum eosinophil cationic proteins in early childhood. J Allergy ClinImmunol. 2004;114(5):1040-5.
  4. Boix E. Eosinophil Cationic Protein: Elsevier 2001.
  5. Acharya KR, Ackerman SJ. Eosinophil granule proteins: form and function. J Biol Chem. 2014;289(25):17406-15.
  6. Jacobsen EA, Helmers RA, Lee JJ, Lee NA. The expanding role(s) of eosinophils in health and disease. Blood. 2012;120(19):3882-90.
  7. BhaishajyaRatnavali K. ChaukambhaSurabharatiPrakashana2016.
  8. Khare CP. Indian Medicinal Plants. 1 ed: Springer-Verlag New York; 2007.
  9. Ghai OP. Ghai Essential Pediatrics: CBS Publishers 2005.
  10. Koh GC, Shek LP, Goh DY, Van Bever H, Koh DS. Eosinophil cationic protein: is it useful in asthma? A systematic review. Respir Med. 2007;101(4):696-705.
  11. S. Fitch VB, B.C. Schock,M. Ennis,M.D. Shields,R. Taylor. Serum eosinophil cationic protein (ECP): reference values in healthy nonatopic children. Allergy. 1999;54:1199 - 203.

[Madhusudan. B. G, Roopa. K. V, K. Lakshmeesh Upadhya, Aravind Bagade, M. V. S. S. T. Subba Rao, Venugopal Reddy, Ahalya Sharma and Rajendra. V. (2019); TO STUDY THE EFFECT OF KANTAKARYAVALEHYA ON EOSINOPHIL CATIONIC PROTEIN (ECP) LEVELS IN CHILDHOOD ASTHMA. Int. J. of Adv. Res. 7 (May). 36-42] (ISSN 2320-5407). www.journalijar.com

Dr. Madhusudan. B. G.
Principal investigator & Corresponding author, Assistant professor, dept. of pg studies in roganidana, JSS Ayurveda Medical college, Mysuru.

DOI:

Article DOI: 10.21474/IJAR01/9002      
DOI URL: http://dx.doi.org/10.21474/IJAR01/9002

Download Full Paper

Download PDF No. of Downloads: 31 | No. of Views: 100