- Cite This Article as
- Corresponding Author
Tuberculosis and Human Immunodeficiency virus have been the two leading causes of infectious diseases associated with mortality worldwide. HIV infection is a well recognised risk factor for both activation of initial infection and reactivation of latent infection. This study was done to assess co-prevalence of TB among HIV infection using GeneXpert MTB/RIF assay. Six hundred and forty three samples with symptoms suggestive of pulmonary tuberculosis were included in this study. Rifampicin resistance was studied by GeneXpert. Sputum specimens were processed for TB detection by Cartridge based nucleic acid amplification testing using Xpert MTB/Rif assay technique. A total of 643 patients with symptoms suggestive of pulmonary tuberculosis in a period of 5 months were studied. Out of these, 287 were reported positive for tuberculosis by CBNAAT. Incidence of tuberculosis in reactive females was 68% and males 60.4% and total prevalence was 28.14% in our study. Prevalence of Rifampicin resistance was 1.09%. It is important to screen MDR-TB cases especially in the immunosuppressed individuals to identify early resistance and also to prevent spread of MDR-TB and Xpert MTB/RIF is a better screening tool.
- Dixit Kumar Jayantibhai Kapadia, Paresh V Dave, Bhavin Vadera, Pranav Govindbhai Patel, Sudhir Chawla, Deepak Saxena. Assessment of tuberculosis prevalence in newly diagnosed HIV infected adults attending care and treatment centre in Gujarat, India. Indian Journal of Community Medicine, 2018, Volume 43, Issue 3, Page 185-189.
- BG Williams, R Granich, L.S.Chauahn, N.S.Dharmshaktu and C. Dey. The impact of HIV/AIDS on the control of Tuberculosis in India.Proceedings of the National academy of sciences of the United States of America. July 5, 2005, 102(27) 9619-9624.
- Prem Prakash Gupta, Adarsh B Mynalli, Aparna Yadav. Diagnostic role of Cartridge Based Nucleic Acid Amplification Test in Diagnosing Tuberculosis in Patients Co-infected with Human Immunodeficiency Virus. Journal of Medical Science and Clinical Research. Volume 05, Issue 05, May 2017, P 21841-21848.
- S. Sowjanya, Ganeswar Behera, V V Ramana Reddy, JV Praveen. CBNAAT: a Novel Diagnostic Tool for Rapid and Specific Detection of Mycobacterium Tuberculosis in Pulmonary Samples. International Journal of health research in modern integrated medical sciences. Oct-Dec 2014, Pg 28-31.
- Tripathi, P Sinha, R Kumari, P Chaubay, A Pandey, S Anupurba. Detection of Rifampicin resistance in Tuberculosis by molecular methods: A report from Eastern Uttar Pradesh, India. Indian Journal of Medical Microbiology, Volume 34, Issue 1, page 94-98, 2016.
- Nella Harshini and B Anuradha. A Study on HIV/TB Co-infection in and around Khammam, Telangana, India. International journal of current Microbiology and Applied Sciences, Volume 6, Number 11, (2017) pp 3698-3705.
- Dewan, S Anuradha, A Khanna, S Garg etal. Role of cartridge based nucleic acid amplification test (CBNAAT) for early diagnosis of pulmonary tuberculosis in HIV. Journal Indian Academy of Clinical Medicine, January 2015, 16(2):114-7.
- Deepak Arora, Neerja Jindal, Renu Bansal and Shilpa Arora. Rapid Detection of Mycobacterium tuberculosis in Sputum samples by Cepheid Xpert Assay: A Clinical Study. Journal of Clinical and Diagnostic Research. 2015 May, 9(5): DC03-DC05.
- Rajnesh Tripathi, Sumedha Kashyap, Prince Chaubey, Alok Prakash Pandey, Shampa Anupurba. Role of cartridge based nucleic acid amplification test in detection of pulmonary tuberculosis in people living with human immunodeficiency virus. Journal of The Academy of Clinical Microbiologists, 2017, Volume 19, Issue 2, page 114-117.
- P. Basavaraj and R. Rajani. CBNAAT: A Novel Tool for Rapid Detection of MTB and Rifampicin Resistance. International Journal of Current Microbiology and Applied Sciences, 2016: 5(12): 383-388.
- GeneXpert MTB/RIF Wikipedia. https://en.wikipedia.org/wiki/GeneXpert_MTB/RIF.
- Desai K, Malek S, Mehtaliya C. Comparative study of ZN staining v/s fluorochrome staining from pulmonary and extra-pulmonary tuberculosis. Gujarat Medical Journal, 2009;64(2): 32-34.
[Y. Umarani, Dulla Sarada, P. Venkateswarulu and N. Gopichand (2020); CBNAAT : A STUDY FROM ACSR MEDICAL COLLEGE, NELLORE Int. J. of Adv. Res. 8 (2). 187-189] (ISSN 2320-5407). www.journalijar.com
Assistant Professor, Department of Microbiology, Siddhartha Medical College, Vijayawada, India.
Article DOI: 10.21474/IJAR01/10451 DOI URL: http://dx.doi.org/10.21474/IJAR01/10451
Share this article
This work is licensed under a Creative Commons Attribution 4.0 International License.