The Relationship between Plasma Ghrelin Concentrations and Carotid Atherosclerosis in Type 2 Diabetes Patients

Abstract: Background: Ghrelin, a peptide hormone which is secreted from the stomach and stimulates growth hormone release and had an orexgenic effect. Ghrelin had beneficial cardiovascular effect through its interaction with growth hormone secretagogue receptor (GHSR) which is widely distributed in the cardiovascular system and upregulated in atherosclerotic arteries but the association between ghrelin and carotid atherosclerosis had conflicting results in the previous studies. Objective: To investigate the association between plasma ghrelin concentrations and carotid atherosclerosis, measured by carotid-intima media thickness (CIMT) in type 2 diabetes patients. Study Design: This is an observational case-controlled study conducted in Ain Shams University hospital. The patient group included 50 patients with T2DM (25 obese and 25 lean patients). The control group included 36 healthy subjects (18 obese and 18 lean subjects). In both groups the fasting plasma ghrelin level, fasting plasma glucose, fasting serum insulin, HbA1C, complete lipids profile, insulin resistance (HOMA-IR) and hs-CRP were measured. The degree of atherosclerosis was assessed by measuring the CIMT. Results: Ghrelin was significantly lower in the diabetic obese patients than the diabetic non obese patient (p<0.001), also, it was lower in the non diabetic obese subjects than the non diabetic non obese subjects (p<0.001). BMI, WHR, FPG, HbA1c, fasting insulin, HOMA-IR, total cholesterol, triglycerides, LDL cholesterol, hs.CRP, and CIMT were significantly higher (p<0.001) in the diabetic obese patients. In the all studies subjects, ghrelin had statistical significant negative correlation with BMI, waist circumference, insulin, HOMA-IR, total cholesterol, LDL cholesterol, hs.CRP, CIMT (p<0.001), HbA1c, and triglycerides (p<0.05). In the diabetic obese patients, ghrelin had statistical significant negative correlation with BMI (r= -0.4, p= 0.03), CIMT (r= -0.6, p= 0.01), and HDL cholesterol (r= -0.6, p=<0.001). In the all studied populations CIMT had highly statistical significant positive correlation with all measured parameters (p<0.001), except with HDL cholesterol and ghrelin; there was highly statistical significant negative correlation (p<0.001). Conclusion: ghrelin had significantly negative correlation with CIMT in the diabetic obese patients and it can be used a marker of subclinical atherosclerosis.

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[Salah Eldin Ahmed Shelbaya, Salwa Seddik Hosny, Rania Sayed Abd Elbaky, Mohammed Fatthalla Elkholy, Matta Makram Anis, Amr Mahmoud Abd ElSamad, Omneya Moguib Saleh, Mohamed Hussen Abbas (2014); The Relationship between Plasma Ghrelin Concentrations and Carotid Atherosclerosis in Type 2 Diabetes Patients Int. J. of Adv. Res. 2 (12). 0] (ISSN 2320-5407).

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