01Jan 2017

Evaluation of Fok-I polymorphisms of VDR gene in Iraqi patients with colorectal cancer

Abstract


Colorectal cancer is the most important cause of cancer death in human in many parts of the world. The vitamin D receptor (VDR) proto-oncogene has been suggested to be involved in the regulation of cell proliferation and differentiation in colorectal cells. Objective: The study was designed to determine a possible relationship between vitamin D receptor (VDR) gene polymorphisms and the risk of colorectal cancer. Methods : We investigated the VDR Fok-I gene polymorphisms in 55 colorectal patients and 60 matched healthy control. The study performed by polymerase chain reaction –based restriction fragment polymorphisms (RFLP). Results : The VDR Fok-I (TT) genotype distribution was significantly increased in patients compared with healthy controls(P ? 0.05 ) , and the carriers of VDR-Fok-I genotype (CT) also significantly increased in patients compared with control(P ? 0.05) . The allele T is associated the risk for disease 34(31%) compared with the healthy control 17 (14%) OR, 2.71, CI 95%, (1.41- 5.20), (P ? 0.05). Conclusion: We suggest that VDR Fok-I might affect the development of colorectal cancer.


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[Salih M. Al-Khafaji (2015); Evaluation of Fok-I polymorphisms of VDR gene in Iraqi patients with colorectal cancer Int. J. of Adv. Res. 3 (4). 0] (ISSN 2320-5407). www.journalijar.com


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