Novel In Situ Modified PVC Membrane Potentiometric Sensors for Determination of Levamisole Hydrochloride in Human Plasma, Urine and Bovine Milk
- Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt
- Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
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This paper is focused on construction and investigating the characteristics of novel levamisole (LVM) in situ modified polymeric membrane sensors. Two sensors were prepared based on the cation exchangers phosphotungstic acid and phosphomolybdic acid (PME1 and PME2, respectively) using dibutyl phthalate as plasticizing solvent. These sensors showed Nernstian slopes of 59.2±0.4 and 58.31±0.4 mV decade-1 in the concentration ranges (1.0x10-6-1.0x10-2 and 1.0x10-5-1.0x10-2 mol L-1) with low detection limits (1.0x10-6 and 2.8x10-6mol L-1) for PME1and PME2, respectively. The sensors were found to be very selective and usable within a wide pH range (2-8). They exhibited fast response times (? 10 s), good stability and long life span (40 and 37 days), respectively. LVM is determined successfully in pure solutions, pharmaceutical preparations and biological fluids (human plasma, urine and bovine milk) using the standard addition and potentiometric titration methods with high accuracy and precision.
[M. M. Khalil,Y. M. Issa, S. M. Abbas and D. G. Mohamed (2016); Novel In Situ Modified PVC Membrane Potentiometric Sensors for Determination of Levamisole Hydrochloride in Human Plasma, Urine and Bovine Milk Int. J. of Adv. Res. 4 (May). 332-344] (ISSN 2320-5407). www.journalijar.com
