30Jun 2016

ASSOCIATION OF STAT4 GENE SINGLE-NUCLEOTIDE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS.

  • Department of Clinical Pathology, Faculty of Medicine, Zagazig University.
  • Department ofRheumatology and Rehabilitation, Faculty of Medicine, Zagazig University.
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Background:- Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disorder, with complex etiology and a strong genetic component. The signal transducer and activator of transcription-4 (STAT4) has been found to be a susceptible gene in the development of SLE in various populations. Aim of the work:- To determine the association of STAT4 (rs7582694) gene polymorphism with thesusceptibility, clinical manifestation, and autoantibodies production in patients of SLE. Patients and methods:- Ninety fourSLE patients andNinety four age and sex matchedhealthyvolunteers (control)were included in this study. Analysis ofSTAT4 genotyping was performed by using Polymerase Chain Reaction- restriction fragment length polymorphism (PCR-RFLP). Results:- The STAT 4 C/C genotype and G/C genotype frequencies were significantly higher in patients than controls ( amounted to 17.0% and 4.3% for C/C genotype and amounted to 42.6% and 25.5% for G/C genotype respectively).The frequency of the STAT4 C allele was significantly higher in patients with SLE compared to control, with frequencies of 38.3% and 17.0% respectively. Conclusion:- STAT4(rs7582694) gene polymorphism was significantly associated with development of SLE and occurrence of some clinical manifestation of the disease.


[Lamiaa A Mohammed, Asmaa Osh, Ahmad Baraka, Ghdada Nageeb and Marwa Abdel-Monem. (2016); ASSOCIATION OF STAT4 GENE SINGLE-NUCLEOTIDE POLYMORPHISM WITH SYSTEMIC LUPUS ERYTHEMATOSUS. Int. J. of Adv. Res. 4 (6). 1694-1700] (ISSN 2320-5407). www.journalijar.com


Marwa Abdel-Monem


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Article DOI: 10.21474/IJAR01/611       DOI URL: http://dx.doi.org/10.21474/IJAR01/611


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