ALTERATIONS OF DETOXIFICATION ENZYME LEVELS IN DIFFERENT TISSUES OF SODIUM FLUORIDE (NaF) TREATED ALBINO MICE

This study reports the effect of Sodium fluoride (NaF) on different tissues i.e. brain, liver and kidney of mice during NaF exposure. The animals are divided into three batches each containing five individuals among which 1st batch served as control, while remaining two batches were treated with 5 and 10ppm NaF for three months respectively. Then the animals were sacrificed and the brain, liver and kidney were isolated for the biochemical assay. Significant changes were observed in the NaF treated animals when compared to the control. Between the two doses the animals exposed to high dose showed significant changes compared to low dose exposed animals. Among the biochemical parameters studied Lipid peroxidation (LP) level, Glutathione s-transferase (GST) and Xanthine oxidase (XOD) activities were increased in all the tissues of the animals exposed to NaF compared to the control, besides decrease in Catalase (CAT) and Superoxide dismutase (SOD) activity. All metabolic enzymes were significantly (p<0.05) altered during treated with two different concentrations of NaF.