A COMPARATIVE STUDY OF SERUM ? HCG CONCENTRATION AND LIPID PROFILE IN PREGNANCY INDUCED HYPERTENSIVE AND NORMOTENSIVE WOMEN IN THIRD TRIMESTER OF PREGNANCY.

Hypertensive disorders are among the commonest and unpredictable medical disorders during pregnancy contributing significantly high to maternal and perinatal morbidity and mortality. Human chorionic gonadotropin (hCG) is a glycoprotein that is produced during pregnancy by the developing embryo and later by the syncytio trophoblast of the placenta mainly. Serum ? hCG is found to be abnormally raised in the urine and serum of pregnant women with pregnancy induced hypertension. The aim of the study was to evaluate the concentration of serum ? hCG and lipid profile level and its correlation with pregnancy induced hypertension. To compare the serum ? hCG and lipid profile level between study and control group. The study was carried out in the department of Biochemistry, Assam Medical College and Hospital, Dibrugarh. The study includes two group cases and controls. The cases included in the study were taken from Obstetrics and Gynaecology Department, Assam Medical College & Hospital during the period of study. The cases comprised of 50 clinically established cases of Pregnancy Induced Hypertension (PIH) in their third trimester and the control group comprised of 50 cases of normotensive pregnant patients in the third trimester. The differences of mean serum ? hCG concentration in cases and in controls were statistically highly significant (p < 0.001). It is also found that there is positive correlation between serum ? hCG concentration with Blood pressure levels both systolic and diastolic pressure. Total Cholesterol, LDL-Cholesterol and Triglycerides were found to high value in cases than controls with statistically significant (p < 0.01) differences. Pregnant women with pregnancy induced hypertension have higher level of serum ? hCG and serum lipid profile in comparison to normotensive women.