Comparison study between biochemical and molecular assays in chronic hepatitis C virus patients in Egypt.
- Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
- Children’s Cancer Hospital– 57357, Cairo, Egypt.
- Al AZhar University, Faculty of Medicine Cairo, Egypt.
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Biochemical parameters and Molecular assays are used in monitoring patients with chronic hepatitis C (CHC). The aim of the present study was to investigate the relationship between biochemical markers and HCV RNA titers in patients with CHC. The study was conducted on 50 known HCV-infected patients, recruitment of patients was random. All samples were collected from the medical department of Al-Azhar University, Cairo, Egypt during the period from January 2013 to June 2014. For the HCV-RNA positive patients, blood samples were collected for different biochemical analysis at the time of routine clinic attendance. All serum samples were assayed for anti-HCV by ELISA. Regarding to molecular assay HCV RNA was detected by RT-PCR. Our results indicated that ALT and AST biochemical markers were increased in CHC in relation with HCV RNA titre on the other hand WBCs and Platelets (PLT) were decreased. In Conclusion the results introduced in this work confirmed that biochemical analysis was correlated to HCV RNA titre and this indicated that Biochemical and Molecular assays are essential for monitoring patients with CHC.
[Mohamed A. Selim, Mohamed T. M. Mansour, Adel A. Mousa, Thany E. Amer and Mohamed M.S. Farag. (2016); Comparison study between biochemical and molecular assays in chronic hepatitis C virus patients in Egypt. Int. J. of Adv. Res. 4 (Jul). 174-180] (ISSN 2320-5407). www.journalijar.com
