IS GLYCINE SUPPLEMENTATION USEFUL IN CREATINE TRANSPORTER DEFICIENCY?

Creatine transport defect (CT1) is a metabolic disorder with neurological symptoms. Glycine, a precursor, inhibit the neurotransmitters and has shown that improve memory retrieval loss and also has a sedative effect by reducing the excitability of nerves cells.The purpose of this study is treat with oral glycine (250 mg/kg/day) in a period of 12 months, a patient with CT1 and compare the clinical, analytic and brain MRS evolution, before and after therapy. The results showed some improvement in concentration, socialization, perception and autonomy. The creatine peak was slightly better and urine creatine level reduces significantly.