Vol. 4 (11) pp. 1947-1953 DOI: 10.21474/IJAR01/2297

BIOLOGICAL EFFECTS OF TOPICAL HYALURONIC ACID ON ORAL ULCER'S HEALING IN RATS RECEIVING METHOTREXATE.

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  • Department of Dentistry, Mansoura University, Egypt.
  • Assistant Professor of Oral Biology, Faculty of Dentistry, Mansoura University.
  • Professor of Oral Biology, Faculty of Dentistry, Mansoura University.
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Abstract

This study was conducted to evaluate the effects of topical application of hyaluronic acid on oral ulcer of rats receiving methotrexate. Forty five male albino rats wgt 200-250 were selected in the study and divided into three groups: I) control group, II) methotrxate group without any treatment, III) methotrexate group+ Hyaluronic acid. Ulcer was inducted after one week of methotrexate injection in groups (II and III). The five rats from each group were sacrificed after 4 days, one week and two weeks consequently. Then the ulcers were taken for histological and ultra structural examination. At the end of this study the hyaluronic acid group showed faster healing of oral ulcer than the control group.

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How to Cite This Article

K. M. Elsherbiny, N. N. Abdel Salam and F. M. Ibrahim. (2016); BIOLOGICAL EFFECTS OF TOPICAL HYALURONIC ACID ON ORAL ULCER'S HEALING IN RATS RECEIVING METHOTREXATE., International Journal of Advanced Research (IJAR), 4 (11), 1947-1953, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/2297

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kholoud moustafa el sherbiny

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