THE IMPACT OF CagA POSITIVE HELICOBACTER PYLORI INFECTION ON BCL-2 EXPRESSION IN GASTRIC MUCOSAL CELLS.
- Department of Biology - College of Education-Al-Iraqia University, Baghdad, Iraq.
- Department of Biology - College of Science – Al-Muthana University, Al-Muthana, Iraq.
- Department of Microbiology - College of Medicine -Al-Nahrain University, Baghdad, Iraq.
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Abstract
More than 50% of Helicobacter pylori strains produce the toxin CagA which introduced to inside the gastric mucosal cells. CagA induce up-regulation of p53 expression whereas, it plays as pro-apoptotic factor. Bcl-2 protein is one of the most important members of the family of anti-apoptosis, hence we aimed to investigate the association between CagA and Bcl-2. Paraffin embedded sections of gastric tissue from thirty patients had been included in this study. In addition, 10 apparently healthy volunteers as a control group. Procedure of In Situ Hybridization was carried out to detect the CagA cytotoxin and immunohistochemistry to evaluate the expression of Bcl-2. In patients group 24/30 cases of patients group gave a moderate staining, 5/30 cases gave substantial staining and only 1/30 cases gave slight staining. the immunoexpression of Bcl-2 in CagA negative cases (mean 44.706± 3.952 S.E.) was higher than that of CagA positive cases (mean 40.267± 1.476 S.E.). The CagA positive strain of H. pylori induce down-regulation of Bcl-2.
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Ahmed S. Abood, Samir S. Raheem, Saad M. Saleh And Nidhal A. Mohammed. (2016); THE IMPACT OF CagA POSITIVE HELICOBACTER PYLORI INFECTION ON BCL-2 EXPRESSION IN GASTRIC MUCOSAL CELLS., Int. J. of Adv. Res., 4 (10), 1968-1973, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/2011
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