Evaluation of Interleuken-6 (IL-6) in Osteoporotic patient\'s before and after Calcium treatment

Bachground:- Osteoporosis (OP) is a disease which is characterized by a low bone mass and a microarchitectural deterioration of the bone tissue, which lead to an enhanced bone fragility and a consequent increase in the fracture sites.There are two types of osteoporosis, Type1: (post menopausal) osteoporosis is caused by an acceleration in the bone turnover as a result of hormone decrease (especially estrogen). Type2: (senile osteoporosis) the impaired of osteoblastic activity for forming new bone, the resorption is either normal or enhanced, resulting in a chronic imbalance in the bone remodeling, leading to defects in the bone mass. Objective:- To evaluate the role of the Interleukin-6(IL-6) in Osteoporotic patient's before and after Calcium treatment. Interleukin-6 is a substance produced in response to injury or trauma of tissue by specialized white blood cells called T-cells, as well as macrophages and endothelial cells. The term interleukin derives from (inter) as a means of communication and (leukin) deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes, it has since been found that interleukins are produced by a wide variety of body cells. However, it also classified as a cytokine, meaning that it is involved in relaying information between cells as both a signaling molecule and a signaling protein. Interleukin-6 plays an important role in regulating cell growth as well as immune functioning. In fact, its release is triggered by tissue damage or infection.Interlukin-6 consider the best marker for function of Immune system. Impaired or uncontrolled interleukin-6 gene expression can produce unwanted immune responses and lead to a variety of diseases, including autoimmune disorders. Patients and Methods :- 60 patients (20 OP cases , 20 OP cases with treatment & 20 healthy controls) were enrolled in this study . The patients studied in this case-control study have been selected from patients attended Rheumatology and Rehabilitation Out-Patient Clinic, Al-Yarmouk Teaching Hospital during the period from November 2014 to January 2016. About five milliliters of venous blood was aspirated using disposable syringes and needles. Measurement of IL-6.