ANTI-BACTERIAL AND ANTI-TUBERCULAR STUDIES OF SOME NOVEL TRIAZINONE DERIVATIVES.
- Department of Chemistry, Mangalore University, Mangalagangotri, Karnataka-574199.
- Department of Bioscience, Mangalore University, Mangalagangotri, Karnataka-574199.
- Abstract
- Keywords
- Cite This Article as
- Corresponding Author
Triazinones and its derivatives are one of the versatile compounds which show significant importance because of its enormous biological activities. The present study deals with the preparation of series of novel [3-tert-butyl-7-(aryl)-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one] (5a-k) (Scheme -2.1) from condensation of [4-amino-6-tert-butyl-3-sulfanyl-1,2,4-triazin-5(4H)-one] (3) and different substituted aryloxy acetic acids (4). The structures of these novel compounds were confirmed and characterized by elemental analysis, FT-IR, 1H-NMR, 13C-NMR, LC-Mass. They were also screened in vitro for their anti-TB, anti-inflammatory and anti-bacterial activities.
[Chandraprabha. V. J, Jagadeesh Prasad D and Prashantha Nayak. (2016); ANTI-BACTERIAL AND ANTI-TUBERCULAR STUDIES OF SOME NOVEL TRIAZINONE DERIVATIVES. Int. J. of Adv. Res. 4 (Oct). 1420-1427] (ISSN 2320-5407). www.journalijar.com
