ANTI-BACTERIAL AND ANTI-TUBERCULAR STUDIES OF SOME NOVEL TRIAZINONE DERIVATIVES.

Triazinones and its derivatives are one of the versatile compounds which show significant importance because of its enormous biological activities. The present study deals with the preparation of series of novel [3-tert-butyl-7-(aryl)-4H-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one] (5a-k) (Scheme -2.1) from condensation of [4-amino-6-tert-butyl-3-sulfanyl-1,2,4-triazin-5(4H)-one] (3) and different substituted aryloxy acetic acids (4). The structures of these novel compounds were confirmed and characterized by elemental analysis, FT-IR, 1H-NMR, 13C-NMR, LC-Mass. They were also screened in vitro for their anti-TB, anti-inflammatory and anti-bacterial activities.