PLASMA MAGNESIUM STATUS IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT DIABETIC NEUROPATHY.

Background :Diabetic peripheral neuropathy (DPN) is a diabetes mellitus (DM) induced disorder of the peripheral nervous system and is characterized by pain and loss of sensation due to symmetrical degeneration of distal peripheral nerves.Studies have shown that magnesium levels are lower in patients with diabetes compared with nondiabetic controls. Objective: to study plasma magnesium status in type 2 diabetic patients with and without diabetic neuropathy . Subjects and Methods; A sample of 110 subjects were included and devided into: group (I) ; including 10 patients without diabetes as control ,group(II)including 74 patients of type 2 diabetic with clinically evident neuropathy ; group (III); including 26 patients of type2 diabetics without clinically evident neuropathy .All patients subjected to detailed medical history , complete clinical examination , fundoscopic examination , laboratory investigations including; RBS; plasma magnesium Levels , HbA1C,Urine analysis, 24 hrs. urinary albumin, estimated GFR., excluding patients with renal faluire , acute myocardial infarction , patients on diuretics, aminoglycosides and other drugs causing magnesium supplements and magnesium containing antacids , pregnant and lactating women. Results: the comparative study consists of 10 patients without diabetes as control(groupI), 74 patients of type 2 diabetes with clinically evident neuropathy (groupII) , 26 patients of type 2 diabetes without clinically evident neuropathy.the avaeage range of plasma magnesium level among 3 groups was 2.12±0.15, 1.47±0.30 , 1.93±0.26 respectively , there is asignificantly statistical difference among the three groups (p<0.001). Conclusion; There is association of hypomagnesaemia with poor glycemic control and also with various long-term complications of diabetes mellitus especially diabetic neuropathy .