Vol. 4 (11) pp. 892-899 DOI: 10.21474/IJAR01/2163

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME O-CRESOL MANNICH BASES

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  • Sudan University of Science and Technology, Faculty of Science.
  • Kordofan University, Faculty of Education.
  • Bisha University, Faculty of Science.
  • University of Bahri, Faculty of Applied and Industrial Chemistry.
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Abstract

Three N-Mannich bases have been synthesized by Mannich reaction of o-cresol with different secondary amines and aqueous formaldehyde. Using a general synthesis protocol the following Mannich bases were obtained: 2-(diethylaminomethyl)-6-methyl phenyl acetate(I) ; 4-(7-methyl-2,3-dihydro-1-benzofuran-3-yl)morpholine (II) ; 1-methyl-4-(7-methyl-2,3-dihydro-1-benzofuran-3-yl)piperazine(III).The constitution of the target molecules have been characterized by using a combination of spectral techniques (UV, IR, 1HNMR and MS). The target molecules were evaluated for their antimicrobial activity against six standard human pathogens using the cup plate agar diffusion bioassay and significant activity was shown by Mannich base (I).

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How to Cite This Article

Abdel Karim M., Waf a O., Nafesa A.G. and Inas O. (2016); SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME O-CRESOL MANNICH BASES, Int. J. of Adv. Res., 4 (11), 892-899, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/2163

Corresponding Author

Mohamed Abdel Karim Mohamed

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