EVALUATION OF MUTATION OF TP53 GENE WITH RISK OF SQUAMOUS CELL CARCINOMA HEAD AND NECK (HNSCC) IN KASHMIRI POPULATION.

Objective:- To find relationship between TP53 mutations and squamous cell carcinoma head and neck (SCCHN) . Study design: Case control study. Setting: Tertiary care hospital (SMHS associated Medical College, Srinagar, Kashmir, India) Participants: 50 cases and 50 controls of squamous cell carcinoma head and neck reported our hospital from 2013-2016. Conclusion: In the present study, HNSCC patients showed 15(30%) GG (Arginine/Arginine), 26(52%) GC (Arginine/Proline) and 9 (18%) CC (Proline/Proline) genotypes and controls shows 31(62%) GG, 11(22%) GC and 8(16%) CC. It was observed that TP53 codon 72 polymorphism was significantly associated with HNSCC. The frequency of homozygous CC (Proline/Proline) genotype was elevated in HNSCC cases compared to controls (P<0.0003,RR 1.845,95% CI 1.264-2.693,OR 3.845), where as frequency of Arg/Arg (P Value = 0.0024,RR 0.563,95% CI 0.3177-0.7967,OR. 0.2627) were elevated in controls compared to cases.