ALTERED EXPRESSION OF MIR-214, MIR-3120 AND PTEN IN IRON-INDUCED EXPERIMENTAL EPILEPSY MODEL OF POST-TRAUMATIC EPILEPSY AND THE EFFECT OF CURCUMIN.

MicroRNAs are known to be involved in the pathogenesis of epilepsies. The objective of the present study was to investigate the changes in expression of miR-3120, miR-214 and Pten gene in iron-induced experimental epilepsy model of post-traumatic epilepsy. In addition, the role of these miRNAs and Pten was also studied in the antiseizure action of curcumin. The results showed that in iron-induced epileptogenesis, expression of miR-3120 and miR-214 is reduced and Pten gene expression is upregulated. The results suggest that these miRNAs may be involved in the pathogenesis of epilepsy. Curcumin’s antiseizure effect is mediated by an increase in the expression of miR-3120 and miR-214 and downregulation of Pten gene expression.