SYSTEMIC ANTIOXIDANTS IN MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS: A SYSTEMATIC REVIEW OF RANDOMISED CONTROL TRIALS AND META–ANALYSIS

  • AssociateProfessor(M.D.S), Room No.1,DepartmentofOralMedicine&Radiology, Govt.DentalCollege&ResearchInstitute, [AffiliatedtoRajivGandhiUniversityofHealthSciences(RGUHS)], Bangalore–560002.
  • PostGraduateStudent, Room No.1,DepartmentofOralMedicine&Radiology, Govt.DentalCollege&ResearchInstitute[AffiliatedtoRajivGandhiUniversityofHealthSciences(RGUHS)], Bangalore-560002.
  • Professor&Head(M.D.S), RoomNo.1, DepartmentofOralMedicine&Radiology, Govt.DentalCollege&ResearchInstitute, [AffiliatedtoRajivGandhiUniversityofHealthSciences(RGUHS)], Bangalore–560002.
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Introduction: Antioxidants relieve the signs and symptoms of oral submucous fibrosis by decreasing the load of free radicals. Aim: The aim of this systematic review was to retrieve and analyse clinical studies investigating systemic antioxidants in the management of OSMF. Material and method: Literature was searched in electronic search engines from 1995 to 2015. The identified titles / abstracts were independently screened according to set criteria for selection of abstracts. The full – text articles retrieved were assessed for eligibility and the eligible studies were assessed for qualitative and quantitative evidence. 9 full text articles were selected and assessed for eligibility. 6 full text articles were eligible for qualitative and quantitative analysis. Meta – analysis was done for mouth opening. Results: The extracted data resulted in 207 subjects using systemic antioxidants. Meta – analysis of the combined data of the studies administering systemic antioxidants as a single entity or in combination with intralesional corticosteroids (n=121) as compared to other interventions (n=121) did not depict significant improvement in mouth opening (SMD = -1.446; 95% CI = -3.332 to -0.439) with significant test of heterogeneity (p = 0.0001 < 0.05). Meta – analysis of the combined data of all the interventional groups (n=207) and control groups (n=203) which depicted that systemic antioxidants as a single entity or in combination with intralesional steroids significantly improve mouth opening v/s controls (SMD = -1.235; 95% CI = -2.263to -0.206) with a significant test of heterogeneity (and p = 0.0001 < 0.05). Conclusion: Although the meta – analysis indicates that antioxidants appear to be effective in management of OSMF, the high degree of heterogeneity and limited amount of data in this systematic review and meta – analysis does not provide a credible evidence to support these observations.

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[Dr. Kondajji Ramchandra Vijayalakshmi, Dr. Ankit Srivastava and Dr. Mubeen Khan (2017); SYSTEMIC ANTIOXIDANTS IN MANAGEMENT OF ORAL SUBMUCOUS FIBROSIS: A SYSTEMATIC REVIEW OF RANDOMISED CONTROL TRIALS AND META–ANALYSIS Int. J. of Adv. Res. 5 (Jan). 1466-1479] (ISSN 2320-5407). www.journalijar.com

Ankit Srivastava
Govt. Dental College & Research Institute [Affiliated to RGUHS]

DOI:

Article DOI: 10.21474/IJAR01/2910      
DOI URL: https://dx.doi.org/10.21474/IJAR01/2910

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