PROTECTIVE POTENTIAL OF CYNODON DACTYLON EXTRACT ON LAMOTRIGINE INDUCED BRAIN TOXICITY IN MICE FETUSES.

  • Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, India
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Lamotrigine (LTG), an antiepileptic drug believed to be safe in pregnancy whereas Cynodon dactylon (CD) is a herb having antioxidant potential, used for the treatment of various diseases including epilepsy in alternative system of medicine. The study was planned to observe the effect of LTG alone and with Cynodon dactylon on growing brain of mice. Lamotrigine was given orally at a dose of 60mg/kg body weight on 7th- 9th gestational day, to the pregnant mice of treated group I (T I) whereas both Lamotrigine (60mg/kg, 7th- 9th day) and Cynodon dactylon juice (0.3 ml , 6th-17th day of gestation) were given to treated group II (T II). Control group (C) received the same volume of distilled water during 6th-17th day of gestation. On 18th day of gestation fetuses from all groups were collected and kept in 10 % formalin for fixation. After three days of fixation the brains were removed from the cranial cavity and observed macro and microscopically. Brain of T I group showed insignificant decrease in weight. The haemorrhagic patches and the prominent blood vessels on various surfaces of brain have been observed in T I group. The macroscopic findings in T II group brain were similar to the control group. The microscopic features of T I brain revealed destruction and oedematous appearance of parenchyma of hippocampus, loss of normal architecture of cortical and subcortical zone, dilated ventricles with disruption of ependymal lining, degeneration and clumping of choroid plexus as compared to control group. Treated group II showed reduction in pathological findings which were appeared in treated group I. Therefore there may be possibility that Cynodon dactylon (CD) fresh juice neutralised the effect of lamotrigine neurotoxicity in growing brain upto certain extent. This may happened due to antioxidant property of CD.

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[Sharda Singh and S.K. Pandey. (2017); PROTECTIVE POTENTIAL OF CYNODON DACTYLON EXTRACT ON LAMOTRIGINE INDUCED BRAIN TOXICITY IN MICE FETUSES. Int. J. of Adv. Res. 5 (Jan). 2151-2155] (ISSN 2320-5407). www.journalijar.com

Dr.Shashi Kant Pandey
Professor, Deptt of anatomy IMS, BHU, Varanasi

DOI:

Article DOI: 10.21474/IJAR01/2989      
DOI URL: https://dx.doi.org/10.21474/IJAR01/2989

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