PREVALENCE AND ANTIMICROBIAL RESISTANCE PATTERN OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATED FROM DIFFERENT CLINICAL SAMPLES.

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Background: Methicillin Resistant Staphylococcus aureus (MRSA) since its emergence, has been a challenge for the community owing to its potential to cause life threatening events like sepsis, endocarditis and osteomyelitis. Aims and objectives: To investigate the prevalence of MRSA in various clinical samples and to find the antibiotic resistance pattern of the MRSA isolates. Materials and Methods: Oxacillin resistance screening agar with 5.5% Nacl and Kirby?Bauer disk diffusion method (cefoxitin 30?g disk) were used for MRSA confirmation and antibiotic resistance testing was done as per CLSI 2016 guidelines. E-test was done for testing sensitivity to Vancomycin. Result: Staphylococcus aureus was isolated from 350 specimens. Out of these 350 isolates, 220 (62.86%) were methicillin sensitive and rest 130 (37.14%) isolates were MRSA. Most of the MRSA isolates were from urine samples (43.71%) followed by pus (24.0%), and putum (11.14%). MRSA isolates showed high resistance to ciprofloxacin (53.38%), and clindamycin (42.31%). linezolid resistance was seen in only 6.15% and all isolates were sensitive to vancomycin. Conclusion: A high prevalence of MRSA (37.14%.) in our institution warrants the judicious use of antibiotics in treating infections caused by Staphylococcus aureus. Vancomycin and linezolid are good treatment options in infections caused by MRSA isolates.

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[Nida Khan, Vineeta Khare, Rahmat Farid and Shadma Yaqoob. (2017); PREVALENCE AND ANTIMICROBIAL RESISTANCE PATTERN OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS ISOLATED FROM DIFFERENT CLINICAL SAMPLES. Int. J. of Adv. Res. 5 (Mar). 2195-2201] (ISSN 2320-5407). www.journalijar.com

Dr. Nida Khan

DOI:

Article DOI: 10.21474/IJAR01/3740      
DOI URL: https://dx.doi.org/10.21474/IJAR01/3740

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