20Jan 2017

VARIABILITY OF MESENCHYMAL VEGFR 1, 2, AND 3 PROTEIN EXPRESSION OFHUMANS AND MURINE SPECIES - A COMPARATIVE ANALYSIS.

  • Center for Stem Cell Research, College of Medicine, King Khalid University, Abha, Saudi Arabia.
  • Department of Microbiology and Parasitology, College of Medicine, King Khalid University, Abha, Saudi Arabia.
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The Vascular Endothelial Growth Factor 1,2,3 (VEGFR 1,2,3) protein sequences from various species like Mus musculus (Mouse), Rattus norvegicus (Rat) and Homo sapiens (Human) were retrieved from SWISS PROT database and compared for their homology and variability.DNAMAN Software was used to create multiple sequence alignment and in assessment of the homology and variability.The results of the phylogenetic tree assessment for VEGFR1, 2, 3 depicts that the sequences from Mus musculus (Mouse) and Rattus norvegicus (Rat) showed high homology when compared with the sequences of the Homo sapiens (Human). The intra sequence homology within the humanVEGFR1,2,3 protein predicted and analyzed for secondary structure show a characteristic variability in the amino acid positions on the random coils, alpha confirmationsand extended strands without significant variation in the length.

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[Ahmed Alrabai, Ahmed AL-Hakami and Harish C Chandramoorthy. (2017); VARIABILITY OF MESENCHYMAL VEGFR 1, 2, AND 3 PROTEIN EXPRESSION OFHUMANS AND MURINE SPECIES - A COMPARATIVE ANALYSIS. Int. J. of Adv. Res. 5 (Jan). 1323-1333] (ISSN 2320-5407). www.journalijar.com

Harish C Chandramoorthy
Center for Stem Cell Research Department of Microbiology and Parasitology College of Medicine, King Khalid University

DOI:

Article DOI: 10.21474/IJAR01/2890      
DOI URL: https://dx.doi.org/10.21474/IJAR01/2890

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