31Jan 2017

BIOLOGICAL IMPACT OF MELATONIN ON THE HEALING OF ALBINO RATS’ TONGUE ULCER

  • Oral Biology Department, Faculty of Dentistry, Mansoura University.
  • Physiology Department, Faculty of Medicine, Mansoura University.
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The pineal gland hormone melatonin is known to have both anti inflammatory and immunomodulatory effect. The present study assessed the effects of intraperitoneal injection of 10 mg/kg melatonin on the healing of induced tongue ulcer. 40 male albino rats were subjected to tongue ulcer using biopsy punch, group I (n=20), received daily 6% ethanol as vehicle. Group II (n=20), received daily melatonin. Specimens were taken after 1st, 4th, 10th day. The histological examination revealed prominent inflammatory cells infiltrations and increased new blood vessels formation. Ultrastructural studies showed marked increase in collagen fibers synthesis. Immunohisochemical results using ? smooth muscle actin indicated significant difference between two groups after 4th days. Melatonin treatment improved the wound healing, both in terms of angiogenesis and orientation of collagen fibers. Considering our results, melatonin has powerful anti-inflammatory properties and has proven to be highly effective.

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[Laila E Amin and Mohamed Adel. (2017); BIOLOGICAL IMPACT OF MELATONIN ON THE HEALING OF ALBINO RATS’ TONGUE ULCER Int. J. of Adv. Res. 5 (Jan). 2191-2199] (ISSN 2320-5407). www.journalijar.com

laila El Sayed Mohamed Amin
Faculty of Dentistry, Mansoura University, Eygpt

DOI:

Article DOI: 10.21474/IJAR01/2996      
DOI URL: https://dx.doi.org/10.21474/IJAR01/2996

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