SITE SPECIFIC DELIVERY OF ANTI-ARTHRITIC DRUG BY GELATIN SURFACE MODIFIED BOVINE SERUM ALBUMIN MICROSPHERES
- Department of Pharmaceutical Sciences.National Institute of Medical Sciences University, Shobha nagar, Jaipur, Rajasthan, India.
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Non-steroidal anti-inflammatory drugs are the most commonly used and widely prescribed drugs all over the world. With the wide advantages, they are also associated with severe Gastro-Intestinal side effects. Developments of novel drug delivery systems have always been a challenge to formulation scientists because of their high instability and economic factor compared to the conventional dosage forms. Thus, the main objective of this review is to present an alternative way of developing NSAIDs as microspheres specifically using albumin polymers, which are playing an increasing role as drug carriers in the clinical setting. Hence, there is a prolonged release of the drug along with minimized side effects. A brief overview of the methods developed for the preparation of albumin microspheres and the most suitable techniques for optimum entrapment of drug have been emphasized. The in-vitro evaluations are also explained. In order to appreciate the medical application possibilities of albumin microspheres in novel drug delivery, some fundamental aspects are also briefly discussed.
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[Agarwal Anuj and Sharma Ashish Kumar. (2017); SITE SPECIFIC DELIVERY OF ANTI-ARTHRITIC DRUG BY GELATIN SURFACE MODIFIED BOVINE SERUM ALBUMIN MICROSPHERES Int. J. of Adv. Res. 5 (Jan). 2960-2967] (ISSN 2320-5407). www.journalijar.com
Department of Pharmaceutical Sciences.National Institute of Medical Sciences University, Shobha nagar, Jaipur, Rajasthan, India.
