Vol. 5 (02) pp. 1287-1293 DOI: 10.21474/IJAR01/3281

MEASUREMENT OF OXIDANT- ANTIOXIDANT MARKERS IN PREMATURE NEWBORN WITH RESPIRATORY DISTRESS SYNDROME.

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  • Department of Pediatrics, college of Medicine, Taif University, Taif, Saudi Arabia.
  • Department of Neonatology, King Abdel Aziz Specialist Hospital (KAASH),Taif, Saudi Arabia.
  • Department of Pediatrics & Neonatology, AlAhrar teaching Hospital, Zagazig, Egypt.
  • Department of Anatomy & Histology, College of Medicine, Taif University, Taif, Saudi Arabia.
  • Department of Histology & Cell Biology, Faculty of Medicine, Zagazig University, Egypt.
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Abstract

Background: Respiratory distress syndrome (RDS) is still an important problem in treatment of preterm infants. The imbalance between the oxidative forces and the antioxidant defense systems was suggested to predispose the lungs to the development of RDS. The present study aimed to investigate the alterations in biochemical parameters of oxidant/antioxidant and its role in development of neonatal RDS. Methods: This case control study included 40 premature neonates with RDS and 50 healthy premature newborns. Quantification of levels of malondialdehyde (MDA), thiobarbituric acid reacting substances (TBARS) along with total antioxidant capacity (reduced glutathione, and superoxide dismutase SOD) in cord blood of healthy premature newborns compared with those with RDS. Results: Status of markers of oxidative stress (MDA, and TBARS) showed a significant increase with depleted levels of total antioxidant capacity of reduced glutathione and SOD in neonatal RDS when compared to healthy newborns. Conclusion: The study concluded oxidative damage and diminished antioxidant defenses in newborns with RDS that was evidenced in severe cases of RDS. This could be of clinical significance in studying the pathophysiology of neonatal RDS.

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How to Cite This Article

Ali K Al-Zahrani, Nader M Mohamed and Mona G Amer. (2017); MEASUREMENT OF OXIDANT- ANTIOXIDANT MARKERS IN PREMATURE NEWBORN WITH RESPIRATORY DISTRESS SYNDROME., Int. J. of Adv. Res., 5 (02), 1287-1293, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/3281

Corresponding Author

Dr Nader Mohamed Mohamed
asisstant prof and consultant of Neonatology, College of Medicine,Taif Universty
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.