Vol. 5 (02) pp. 2481-2488 DOI: 10.21474/IJAR01/3430

COMPARISON OF EFFICACY OF INFUSIONS OF DEXMEDETOMIDINE VERSUS BUTORPHANOL AS SEDATIVE & ANALGESIC IN SHORT GENERAL ANAESTHESIA IN DAY CARE GYNAECOLOGICAL SURGERIES.

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Abstract

Background And Goals: Development of selective alpha 2 adrenoceptor agonists may provide a new concept for the administration of periopertive anaesthesia & analgesia in day care surgeries.Goal of this study was to compare Inj.Dexmedetomidine&Inj.Butorphanol with respect to time required for onset & offset of sedation, quality of intraoperative as well as postoperative analgesia & the time required for post-operative recovery. Methods: After obtaining permission from Institutional Ethical Committee (IEC), study was conducted in 40 patients of ASA I and || divided into 2 groups A & B by computer generated random number table. Patients, in group A received injDexmedetomidine 1 mcg/kg i.v and group B received inj.Butorphanol 10 mcg/kg i.v, in infusion over 10 minutes prior to induction. Induction was done with injPropofol i.v 2mg/kg & maintained with 33% O2, 66%N2O & 0.6-0.8% of isoflurane with patient breathing spontaneously. Throughout the surgery the sedation and analgesia was maintained with injDexmedetomidine 0.7 microgram/kg/hr infusion in group A and with injButorphanol 2 microgram/kg/hr in group B. Patients were evaluated in postoperative recovery room with help of Visual Analogue Scale (VAS) for pain, Ramsay Sedation Score & Standard Aldrete Score for recovery. Results: Demographically, the two groups were similar. Requirement of inhalationalanaesthetic agents was significantly reduced in the group A (p < 0.05).VAS was significantly less(2.75 � 0.44) in the group B after 90 min and earlier rescue analgesia was given in group A ( p < 0.05). Eye opening was earlier (45.5 � 23.61) in group A and was highly significant (p < 0.001). Postop recovery was significantly improved (9.8 � 0.41) with dexmeditomidinegroup. Conclusion: Dexmedetomidine produces better sedation and analgesia without significant adverse effects and can be used as sole sedative and analgesic for day care surgery patients with better recovery.

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How to Cite This Article

Anuja Agrawal, Jitender Chauhan and Hetal Parikh. (2017); COMPARISON OF EFFICACY OF INFUSIONS OF DEXMEDETOMIDINE VERSUS BUTORPHANOL AS SEDATIVE & ANALGESIC IN SHORT GENERAL ANAESTHESIA IN DAY CARE GYNAECOLOGICAL SURGERIES., Int. J. of Adv. Res., 5 (02), 2481-2488, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/3430

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Dr Jitender Chauhan

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