A COMPARATIVE STUDY BETWEEN 0.5% CENTBUCRIDINE HCL AND 2% LIGNOCAINE HCL WITH ADRENALINE (1:200,000): SYSTEMATIC REVIEW AND META-ANALYSIS.

Purpose: The aim of the present study was to identify significant differences between centbucridine and lignocaine with regard to efficacy of local anesthesia, cardiovascular stability, and side effects of the local anesthetics. Materials and methods: We performed a systematic and electronic search of several databases using specific keywords, and a manual search through February 2017. The inclusion criteria were clinical human studies, including randomized controlled trials (RCTs), controlled clinical trials (CCTs), and retrospective studies, with the aim of comparing the two drugs in dental/oral surgical practice. Meta-analysis was used to select a fixed or random effects model according to the heterogeneity of the studies. Heterogeneity was assessed using Cochran's Q - test and I2. The standard difference in means (SDM) was used as the effect measure for all variables. The results were graphically presented using Forest plot. Funnel plot was used to assess publication bias. The significance level was set at p-value ≤ 0.05 Results: Three studies met our inclusion criteria. No statistically significant difference was found between the 2 groups regarding onset of anesthesia (P = 0.870), duration of anesthesia (p=0.327), depth of anesthesia (P=0.794), and pulse rate after 10 minutes (p=0.087). A statistically significant difference was found between the two drugs regarding pulse rate after 30 minutes (p = 0.017). Conclusion: The results of the meta-analysis have shown that Centbucridine significantly reduced pulse rate 30 minutes after dental extractions compared with the lignocaine.