CLINICAL PRESENTATION OF POLYCYSTIC OVARY SYNDROME AMONG SAUDI ARABIAN WOMEN ? JEDDAH ? SAUDI ARABIA.
- Battarjee Medical College.
- King Abdulaziz University.
- Um Alqura University.
- Ibn Sina National College.
208 Downloads
831 Views
Abstract
Background: Polycystic ovary is a highly variable condition with a wide array of presentations. The Polycystic ovary syndrome should meet at least two of the following three criteria: oligo- or anovulation; clinical and/or biochemical signs of hyperandrogenism; polycystic ovaries on ultrasound. The prevalence of PCO is largely unknown in Saudi Arabia.
Objectives: The aim of this study was to investigate the reproductive hormones levels in patients with PCOS in addition to the effect of age and body mass index (BMI) on the hormonal findings and ultrasound & to determine the clinical, biochemical and etiologic features of hirsutism in Saudi females.
Methodology: A cross sectional study has been conducted among total of 183 patients diagnosed with PCOS have been assessed clinically along with measuring the level of reproductive hormones in Obstetrics and Gynecology Clinic at King Abdul-Aziz hospital and oncology center in Jeddah, Saudi Arabia, between June 2015 and June 2016.
Conclusion: Elevated levels of LH/FSH and testosterone and reduced FSH, SHBG, and progesterone were predictors of PCOS. This was independent of BMI or age. Future studies with larger sample size and data on insulin levels are needed for greater understanding of the manifestation of PCOS in the Saudi population.
How to Cite This Article
Najla Abdullahh Alsibyani, Mohammed A Malibary, Ahmad Ayed Derham, Abdulrahman Abdulelah Almnabri, Nuha Khalid Jazzar, Rzan Waleed Melibari, Reem Aaidh Alnefayi and Alanoud Saed Alnefaie. (2017); CLINICAL PRESENTATION OF POLYCYSTIC OVARY SYNDROME AMONG SAUDI ARABIAN WOMEN ? JEDDAH ? SAUDI ARABIA., International Journal of Advanced Research (IJAR), 5 (03), 1872-1876, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/3704
Corresponding Author
Article Analytics
References
- Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries.Am J Obstet Gynecol.?1935;29:181?91
- Shaista Salman Guraya, Prevalence and ultrasound features of Polycystic ovaries in young unmarried Saudi females, Jounal of Microscopy and Ultrastructure:1(2013) 30-34.
- Eshre R. Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome. Fertility and Sterility 2004;81(1):19.
- Adams J, Polson DW, Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism.?Br Med J (Clin Res Ed)?1986;293:355?9
- Dewailly D, Catteau-Jonard S, Reyss A-C, Leroy M, Pigny P. Oligoanovulation with polycystic ovaries but not overt hyperandrogenism.Journal of Clinical Endocrinology and Metabolism 2006;91(10):3922?7.
- Legro RS, Barnhart HX, Schlaff WD, Carr BR, Diamond MP, Carson SA, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. New England Journal of Medicine 2007;356(6):551?66.
- Alemzadeh R, Kichler J, Calhoun M. Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adolescent girls with polycystic ovary syndrome.?Eur J Endocrinol.?2010;162:1093?9.
- Hassa H, Tanir HM, Yildiz Z. Comparison of clinical and laboratory characteristics of cases with polycystic ovarian syndrome based on Rotterdam's criteria and women whose only clinical signs are oligo/anovulation or hirsutism.?Arch Gynecol Obstet.?2006;274:227?32.
- Setji TL, Brown AJ. Polycystic ovary syndrome: Diagnosis and treatment.?Am J ed.?2007;120:128?32.
- Franks S, Kiddy D, Sharp P, Singh A, Reed M, Sepp?l? M, et al. Obesity and polycystic ovary syndrome.?Ann N Y Acad Sci.?1991;626:201?6.
- Penttil? TA, Anttila L, T?rm? A, Koskinen P, Erkkola R, Irjala K. Serum free testosterone in polycystic ovary syndrome measured with a new reference method.?Fertil Steril.?1996;65:55?60.
- Iwasa T, Matsuzaki T, Murakami M, Shimizu F, Kuwahara A, Yasui T, et al. Reproducibility of luteinizing hormone hypersecretion in different phases of the menstrual cycle in polycystic ovary syndrome.?J Obstet Gynaecol Res.?2009;35:514?9.
- Iwasa T, Matsuzaki T, Minakuchi M, Tanaka N, Shimizu F, Hirata Y, et al. Diagnostic performance of serum total testosterone for Japanese patients with polycystic ovary syndrome.?Endocr J.?2007;54:233?8.
- In addition, mean concentration of testosterone was higher in patients with PCOS compared to controls.
- van Santbrink EJ, Hop WC, Fauser BC. Classification of normogonadotropic infertility: Polycystic ovaries diagnosed by ultrasound versus endocrine characteristics of polycystic ovary syndrome.?Fertil Steril.?1997;67:452?8.?[PubMed]
- Laven JS, Imani B, Eijkemans MJ, Fauser BC. New approach to polycystic ovary syndrome and other forms of anovulatory infertility.?Obstet Gynecol Surv.?2002;57:755?67.?[PubMed]
- Taylor AE, McCourt B, Martin KA, Anderson EJ, Adams JM, Schoenfeld D, et al. Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome.?J Clin Endocrinol Metab.?1997;82:2248?56.
- Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women.J Clin Endocrinol Metab.?1961;21:1440?7.
- Susan M Sirmans and Kristen A Pate. Epidemiology, diagnosis, and management of polycystic ovary syndrome. 2013, Dovepress: https://doi.org/10.2147/CLEP.S37559
- Bronstein J1,?Tawdekar S,?Liu Y,?Pawelczak M,?David R,?Shah B. Age of onset of polycystic ovarian syndrome in girls may be earlier than previously thought. J Pediatr Adolesc Gynecol.?2011 Feb;24(1):15-20. doi: 10.1016/j.jpag.2010.06.003.
- Katsikis I, Karkanaki A, Misichronis G, Delkos D, Kandaraki EA, Panidis D. Phenotypic expression, body mass index and insulin resistance in relation to LH levels in women with polycystic ovary syndrome.Eur J Obstet Gynecol Reprod Biol.?2011;156:181?5.
- Dale PO, Tanbo T, Vaaler S, Abyholm T. Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: Evidence of two distinct populations.Fertil Steril.?1992;58:487?91.
- Grulet H, Hecart AC, Delemer B, Gross A, Sulmont V, Leutenegger M, et al. Roles of LH and insulin resistance in lean and obese polycystic ovary syndrome.Clin Endocrinol (Oxf)?1993;38:621?6.
- Banaszewska B, Spaczyński RZ, Pelesz M, Pawelczyk L. Incidence of elevated LH/FSH ratio in polycystic ovary syndrome women with normo-and hyperinsulinemia.Rocz Akad Med Bialymst.?2003;48:131?4.
- Toprak S, Y?nem A, Cakir B, G?ler S, Azal O, Ozata M, et al. Insulin resistance in nonobese patients with polycystic ovary syndrome.Horm Res.?2001;55:65?70.
- Tropeano G, Vuolo IP, Lucisano A, Liberale L, Barini A, Carfagna P, et al. Gonadotropin levels in women with polycystic ovary syndrome: Their relationship to body weight and insulin levels.J Endocrinol Invest.?1996;19:139?45.
- Johnstone EB, Davis G, Zane LT, Cedars MI, Huddleston HG. Age-related differences in the reproductive and metabolic implications of polycystic ovarian syndrome: Findings in an obese, United States population.Gynecol Endocrinol.?2012;28:819?22.
- Glintborg D, Mumm H, Ravn P, Andersen M. Age associated differences in prevalence of individual Rotterdam criteria and metabolic risk factors during reproductive age in 446 Caucasian women with polycystic ovary syndrome.Horm Metab Res.?2012;44:694?8.
- Robinson S, Rodin DA, Deacon A, Wheeler MJ, Clayton RN. Which hormone tests for the diagnosis of polycystic ovary syndrome??Br J Obstet Gynaecol.?1992;99:232?8.
This work is licensed under a Creative Commons Attribution 4.0 International License.





