Vol. 5 (04) pp. 1233-1237 DOI: 10.21474/IJAR01/3939

THE IMPACT OF TSH LEVEL ON ALBUMINURIA AND GLOMERULAR FILTRATION RATE IN TYPE 2 DIABETES MELLITUS.

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  • Department of Internal Medicine, Cairo University.
  • Department of Chemical Pathology, Cairo University.
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Abstract

Purpose/Aim: Subclinical hypothyroidism(SCH) is common in patients with type 2 diabetes. The aim of this work is to investigate for the presence of an association between subclinical hypothyroidism and chronic kidney disease (CKD) in patients with type 2 diabetes mellitus. Materials and Methods: The study included 100 subjects with diabetes mellitus and normal serum creatinine from Kasr EL Ainy Hospital outpatient clinic of diabetes mellitus and endocrinology. TSH, FT4, urine albumin/creatinine ratio and eGFR were measured. Other diabetic complications were sought. A cut-off value of TSH 3.5?IU/L was used to define SCH. Results: Twelve patients from the study cohort had SCH. Regression analysis indicated that higher TSH levels were associated higher A1c (regression coefficient ? SE, 2.63 ?0.26), increased albuminuria (regression coefficient ? SE, 15.45 ?3.03) and decreased eGFR (regression coefficient ? SE, -31.89 ?3.20). Conclusions: SCH patients have a higher risk for albuminuria and decreased eGFR, thus are at a higher risk for progression of diabetic nephropathy. This data highlights the importance of thyroxine replacement for even the smallest degrees of TSH elevation in patients with type 2 diabetes mellitus.

How to Cite This Article

Rasha M Abdel Samie, Ula M. Al-Jarhi, Mona M. Fathy and Mona Mohsen. (2017); THE IMPACT OF TSH LEVEL ON ALBUMINURIA AND GLOMERULAR FILTRATION RATE IN TYPE 2 DIABETES MELLITUS., International Journal of Advanced Research (IJAR), 5 (04), 1233-1237, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/3939

Corresponding Author

Ula Mabid Al-Jarhi
Department of Internal Medicine, Cairo University

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