Vol. 5 (04) pp. 1926-1930 DOI: 10.21474/IJAR01/4033

SPECTROSCOPIC DETERMINATION OF HYDROCHLOROTHAIZIDE BY USING HYDROTROPIC SOLUBILISING AGENT.

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  • Assistant Professor,Department of Pharmaceutical Chemistry, GIPER, Limb,Satara: 415015, India.
  • Department of Chemistry GIPER, Limb, Satara: 415015, India
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Abstract

Analysis of drug utilized the organic solvent which are costlier, toxic, and causing environment pollution. Hydrotropic solution may be a proper choice to preclude the use of organic solvents so that an attempt has been made to develop simple, accurate, novel, safe and precise spectrophotometric method for estimation of poorly-water soluble drug Hydrochlorothaizide. Solubility of Hydrochlorothaizide is increased by using tri-sodium citrate and urea solution as hydrotropic agent. There was more than 28 fold solubility enhanced in hydrotropic solution as compare with distilled water. The Hydrochlorothaizide shows the maximum absorbance at 271 nm. At this wavelength hydrotropic agent and other tablet excipients do not shows any significant interference in the spectrophotometric assay. The developed method was found to be linear in the range of 5-25 μg/ml with correlation coefficient (r2) of 0.999. The mean percent label claims of tablets of Hydrochlorothaizide in marketed formulation estimated by the proposed method were found to be 99.91?0.04 respectively. The developed methods were validated according to ICH guidelines and values of accuracy, precision and other statistical analysis were found to be in good accordance with the prescribed values. As hydrotropic agent used in the proposed method so this method is eco-friendly and it can be used in routine quantitative analysis of drug in bulk drug and dosage form in industries

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References

  1. Jain N, Jain R, Thakur N, Gupta B, Banweer J, Jain S. Novel spectrophotometric quantitative estimation of hydrochlorothiazide in bulk drug and their dosage forms by using hydrotropic agent. Int. J. Appl. Pharma. 2010; 2(3): 1114.
  2. Gurumurthy Venkatesh et al,Spectrophotometric estimation of acyclovir using hydrotropic solubilsation phenomenon, Journal of Pharmacy Research , 2012,5(2),849-851.
  3. K R Sreejith et al, A review on analytical methods based on hydrotropic phenomenon, European Journal Of Pharmaceutical And Medical Research, 2015,2(5), 1293-1319.
  4. K. Nangare et al, Development And Validation Of Uv Spectrophotometric Methods For Estimation Of Efavirenz In Bulk And Tablet Dosage Form, Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry. 2(3), 2014, 134 - 144.
  5. P. R. Chowdary et al, Recent Research On Formulation Development Of BCS Class II Drugs ? A Review, International Research Journal of Pharmaceutical and Applied Sciences (IRJPAS),2013, 3(1): 173-181.
  6. Gurumurthy et al, Application of mixed cosolvency concept in spectrophotometricestimation of acyclovir tablets, Pelagia Research Library ,Der ChemicaSinica, 2011, 2(6):198-203.
  7. K. Maheshwari et al,Novel Spectrophotometric Estimation Of Some Poorly Water Soluble Drugs Using Hydrotropic Solubilizing Agents, Indian Journal Of Pharmaceutical Sciences, 2006, 195-198.
  8. Siladityabehera et al,Uv-Visible Spectrophotometric Method Development And Validation Of Assay Of Paracetamol Tablet Formulation, J Anal Bioanal Techniques 2012, 3(6):1-6
  9. Kapadiyanidhi et al, Hydrotropy: A Promising Tool For Solubility Enhancement: A Review 2011, 3(2): 26- 33
  10. Ruchi Jain et al,Quantitative Estimation Of Meloxicam : A Novel Approach Using Hydrotropic Solubilization Technique, Asian J Pharm Clin Res,2013, 330-334
 

How to Cite This Article

Chetana D.Patil, Balaji W.Matore and Pallavi S.Dhekale, Digamber N.Bhosale (2017); SPECTROSCOPIC DETERMINATION OF HYDROCHLOROTHAIZIDE BY USING HYDROTROPIC SOLUBILISING AGENT., Int. J. of Adv. Res., 5 (04), 1926-1930, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/4033

Corresponding Author

Chetana Patil
Department of Pharmaceutical Chemistry, GIPER, Limb,Satara: 415015, India.
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.