Vol. 5 (04) pp. 2085-2092 DOI: 10.21474/IJAR01/4055

ANTI-ULCER ACTIVITY OF BAICALEIN-7-O-GLUCURONIDE ISOLATED FROM PERSICARIA GLABRA FLOWERS AGAINST PYLORIC LIGATION INDUCED ULCER IN ALBINO RATS.

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  • Department of Chemistry, Thiru.Vi.Ka. Government Arts College, Thiruvarur, Tamilnadu, India - 610 003
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Abstract

To isolate a flavonoid glycoside from flowers of Persicaria glabra using chromatography separation techniques, spectral characterization and its anti-ulcer activity. The isolated compound was purified, analyzed and characterized by chemical tests, HPLC and spectroscopic methods such as UV, IR, 1H-NMR and 13C-NMR. Anti-ulcer activity of Baicalein-7-O-glucuronide (250 mg) and methanolic extract (500 mg) of Persicaria glabra was examined on pyloric ligated induced ulcer model in rats. Omeprazole was used as standard. The anti-ulcer activity of flower extract of Persicaria glabra was estimated with the help of pH, gastric volume, free acidity, total acidity and ulcer index. The extract showed substantial reduction in pH, gastric volume and ulcer index in dose dependent manner as compared to control. The extract did not produce any toxic effects even at high doses.

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How to Cite This Article

Vijayaraj Chellaiyan and Senguttuvan Swaminathan (2017); ANTI-ULCER ACTIVITY OF BAICALEIN-7-O-GLUCURONIDE ISOLATED FROM PERSICARIA GLABRA FLOWERS AGAINST PYLORIC LIGATION INDUCED ULCER IN ALBINO RATS., Int. J. of Adv. Res., 5 (04), 2085-2092, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/4055

Corresponding Author

Prof. C. Vijayaraj,
Assistant professor of chemistry,
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.