20May 2017

EFFECT OF THE HYDROALCOHOLIC EXTRACT OF OLEA EUROPEA LEAVES ON GLUCOSE TOLERANCE AND PLASMA LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC RATS.

  • Biochemistry Dept. College of Medicine, TaifUniversity, Taif, KSA.
  • Faculty of Specific Education, Mansoura University, Mansoura, Egypt.
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This work was conducted to study the effects of the hydroalcoholic extract of olive (Oleaeuropea L) leaves on glucose tolerance and plasma lipids level in alloxan-induced diabetic rats. Two experiments were carried out, in the first one, the diabetic rats were divided into three groups (8 rats each) namely; control group which received normal saline, reference group which received glipiside (an antidiabetic drug) and extract group which received the hydroalcoholic extract of olive leaves (400 mg/Kg b.w.) and their blood sugar levels were determined every 2 hours. In a long term experiment, the diabetic rats were divided randomly into two groups (8 rats each), one group received daily the hydroalcoholic extract of olive leaves in a dose of 400 mg/Kg b.w. dissolved in 1.0 ml normal saline and the second group (diabetic control) received normal saline only (1.0 ml) by using stomach tube during the experiment period. Oral glucose tolerance test was evaluated weekly during the experiment period, in addition to insulin levels and lipid profile. The results revealed that the hydroalcoholic extract of olive leaves improved the glucose tolerance (by decreasing the area under the plasma glucose concentration time curves (AUC); lowered the fasting plasma glucose (FPC) level and increased insulin secretion in the extract-treated group as compared to control. Also, the obtained results showed significant reductions in total cholesterol (TC), triglycerides (TG) and low density lipoprotein (LDL-c) levels in the plasma of the extract-treated group when compared with the control group. This study demonstrated that intake of olive leaves or its extract, either in a tea drink form or by adding it to the food, has beneficial effects on glucose tolerance and lipid metabolism especially in individuals with non-insulin dependent diabetes (NIDD).

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[Elbadrawy and Mohammed Alblihed. (2017); EFFECT OF THE HYDROALCOHOLIC EXTRACT OF OLEA EUROPEA LEAVES ON GLUCOSE TOLERANCE AND PLASMA LIPID PROFILE IN ALLOXAN-INDUCED DIABETIC RATS. Int. J. of Adv. Res. 5 (May). 486-494] (ISSN 2320-5407). www.journalijar.com

Elsayed Elbadrawy
Biochemistry department, college of Medicine, Taif University, Taif, KSA

DOI:

Article DOI: 10.21474/IJAR01/4135      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4135

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