Vol. 5 (05) pp. 1789-1793 DOI: 10.21474/IJAR01/4310

MICROWAVE ASSISTED PICTET-SPENGLER SYNTHESIS OF SOME TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR BIOLOGIAL EFFICACY STUDIES.

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  • Assistant Professor and Head, Department of Chemistry, M. B. Patel College, Deori, 441901(M.S.), India.
  • Associate Professor and Head, Department of Chemistry, Bhawabhuti. College, Amgaon, 441902(M.S.), India.
  • Associate Professor, Govt. Vidarbha Institute of Science and Humanities, Amravati, 444604(M.S.), India.
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Abstract

In the present research article, a one pot synthesis of novel 1,2,3,4-tetrahydro-6,7-dimethoxy-1-(substitutedphenyl)isoquinoline(THIQ) derivatives using 2-(3,4-dimethoxy)phenylethylamine, substituted benzaldehyde with toluene in tetrahydrofuran(THF) under microwave condition is reported. The structures of the newly synthesised compounds were confirmed using modern analytical IR, NMR and MS techniques. The synthesized THIQ derivatives were screened for antibacterial activities against gram positive and gram negative bacteria. The biological efficacies of the synthesized derivatives were investigated in the form of zone of inhibition (mm) against E. coli, S. aureus and P. aeruginosa. Few of the derivatives have been found to possess significant antibacterial activities and can have potential applications in pharmacological/medical science.

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How to Cite This Article

Sachin S. Chourasia, Pralhad K. Rahangdale and Farhin Inam. (2017); MICROWAVE ASSISTED PICTET-SPENGLER SYNTHESIS OF SOME TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR BIOLOGIAL EFFICACY STUDIES., Int. J. of Adv. Res., 5 (05), 1789-1793, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/4310

Corresponding Author

Dr.P.K.Rahangdale
Ex-chairman, board of studies in chemistry, RTM, Nagpur University, Nagpur
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