COAGULATION PROFILE AS IMPORTANT MARKERS IN PREECLAMPSIA AND ECLAMPSIA

  • Assistant Professor, Department of Pathology, Darbhanga Medical College, Darbhanga.
  • Senior Resident, Department of surgery, Darbhanga Medical College, Darbhanga.
  • Professor and H.O.D, Department of Pathology, Darbhanga Medical College, Darbhanga.
Crossref Cited-by Linking logo

  • Abstract
  • Keywords
  • References
  • Cite This Article as
  • Corresponding Author

Aim: To establish that coagulation profile is important marker and can be used to predict progression of preeclampsia and eclampsia. Design: Retrospective study done at Darbhanga Medical College, Bihar from December 2003- January 2006. Materials and methods: 140 pregnant women between 17yrs to 30 yrs age were included in the study. Among these women there were 41 %( n=68) cases of preeclampsia, 23% (n=32) cases of eclampsia and remaining 29 %( n= 40) women with normal pregnancy in third trimester were taken as control. 64.7 % (n=44) of preeclamptic women were 20 yrs to 25 yrs of age. 50% (n=16) women with eclampsia were 20-25 yrs of age. Nulliparous women were higher in pre-eclamptic group (52.9%) whereas only 25% of eclamptic women were nulliparous. In this study group all patients except 4 were in third trimester of pregnancy, 47.1% of pre eclamptic group and 37.5% of eclamptic group were in early third trimester of pregnancy. Four eclamptic women (12.5%) were in 25 weeks gestation. The coagulation parameters tested were bleeding time, clotting time, prothrombin time, thrombin time, activated partial thromboplastin time, plasma fibrinogen, and platelet count. The values of coagulation parameters were statistically analysed in preeclamptic, eclamptic and control group. Results: Bleeding time (B.T): ? Difference in mean value of preeclamptic (2.45 ? 0.48 S.D.) with that of normal (2.3 ?0.19 S.D.) difference was insignificant (p<0.1) ? Difference in mean value of B.T. of eclamptic (2.94 ? 0.47 S.D.)with that of normal (2.3 ?0.19 S.D.) was significant (p<0.001) Clotting time (C.T.): ? Difference in mean value of C.T. of preeclamptic (4.23? 0.37 S.D.) and normal (4.2 ?O.37 S.D) was statistically insignificant (p<0.1). ? Difference in mean value of C.T. of eclamptic (5.19 ? 0.38 S.D.) and normal women (4.2 ?O.37 S.D) was statistically significant (p<0.001). Prothrombin time (P.T.): ? Difference in mean value of P.T. of preeclamptic (0.96 ? 0.05 S.D.) and normal (0.92 ? 0.1 S.D) was statistically insignificant (p<0.1). ? Difference in mean value of P.T. of eclamptic (1.09 ? 0.13 S.D.) and normal women (0.92 ? 0.1 S.D) was statistically significant (p<0.001). Thrombin time (T.T): ? Difference in mean value of T.T. of preeclamptic (0.99 ? 0.13 S.D.) and normal (0.86 ? 0.09 S.D) was statistically significant (p<0.001). ? Difference in mean value of T.T. of eclamptic (1.09 ? 0.2 S.D.) and normal women (0.86 ? 0.09 S.D) was statistically significant (p<0.001). Activated partial thromboplastin time (APTT): ? Difference in mean value of APTT of preeclamptic (49.96 ? 8.72 S.D.) and normal (55.59 ? 12.19 S.D) was statistically insignificant (p<0.1). ? Difference in mean value of APTT of eclamptic (59.26 ? 11.65 S.D.) and normal women (55.59 ? 12.19 S.D) was statistically insignificant (p<0.1). Plasma fibrinogen: ? Difference in mean value of Plasma fibrinogen of preeclamptic (350.23 ? 58.53 S.D.) and normal (492.17 ? 82.73 S.D) was statistically significant (p<0.001). ? Difference in mean value of plasma fibrinogen of eclamptic (227.50 ? 57.45 S.D.) and normal women (492.17 ? 82.73 S.D) was statistically significant (p<0.001). Platelet count: ? Difference in mean value of platelet count of preeclamptic (2 ? 0.75 S.D.) and normal (2.43? 0.26 S.D) was statistically significant (p<0.001). ? Difference in mean value of plasma fibrinogen of eclamptic (1.68 ? 0.66 S.D.) and normal (2.43? 0.26 S.D) was statistically significant (p<0.001).

  1. Coagulation Parameters in Pre-eclamptic and Eclamptic Patients - A Comparative Study of 90 Cases Upam Kr. Sharma1 , Reena Kouli2 , Ramesh Sonowal3 , Projnan Saikia4
  2. WHO recommendations for Prevention and treatment of pre-eclampsia and eclampsia
  3. Ahmed y, van iddekinge B, Paul C, Sullivan MHF, Elder MG ?Retrospective analysis of platelet numbers and volumes in normal pregnancy andin preeclampsia.Br J Obs Gyn,100:216-220;1993
  4. Biland,B and Duckart F. Coagulation factors of the newborn and his mother
  5. Weiner CP, Brandt J. Plasma antithrombin-III activity: an aid in the diagnosis of pre-eclampsia-eclampsia. Am J Obstet Gynecol. 1982;142:275-281.
  6. Chauhan P, Rawat U, Bisht V, Purohit RC. "Comparison of Coagulation Profile in Pre-Eclamptic and Eclamptic Patients with Normotensive Pregnant Patients". Journal of Evolution of Medical and Dental Sciences. 2014;3:3208- 3215.
  7. Vrunda JK, Shaila S. Lowered platelet count: A Prognostic Index in Pregnancy Induced Hypertension. J Obstet Gynecol Ind. 2004;54:235-6.
  8. Sultana R, Karim SM, Atia F, Ferdousi S, Ahmed S. Platelet Count In Preeclampsia. J. Dhaka National Med. Coll. Hos. 2012; 18: 24-26
  9. Coagulation Profiles in PIH ?a) To Determine Coagulation Index to Distinguish Severe Preeclampsia from Normal Pregnancy b) To Assess the Correlation of Coagulation Parameters in Normal Pregnancy & in Varying Grades of Preeclampsia Mirza Asif Baig. MD (Pathology) Former Assistant Professor BLDUs Shri B. M. Patil Medical College, Hospital & Research Centre Bijapure, Karnataka, India
  10. Brown MA, Lindheimer MD, de Swiet M, van Assche A, Moutquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy. 2001; 20: IX-XIV. [7] Cunningham F.G, Kenneth J. Leveno, StevenL. Bloom. Pregnancy induced hypertention. In: Kenneth J. Leveno, StevenL. William?s Obstetrics, 23rd ed. New York ; 2010. p.706-56

[Talat Fatma, Shamim Khurrum Azmi, and Ajit Kumar Chaudhary. (2017); COAGULATION PROFILE AS IMPORTANT MARKERS IN PREECLAMPSIA AND ECLAMPSIA Int. J. of Adv. Res. 5 (May). 2211-2218] (ISSN 2320-5407). www.journalijar.com

Dr Talat Fatma
1. Assistant Professor, Department of Pathology, Darbhanga Medical College, Darbhanga.

DOI:

Article DOI: 10.21474/IJAR01/4370      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4370

Download Full Paper

Download PDF No. of Downloads: 169 | No. of Views: 579