28Jun 2017

SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASES AND THIAZOLIDINONE DERIVATIVES AND THEIR MICROBIAL EVALUATION.

  • V. S. Patel College of Arts and Science Bilimora.
  • Department of Chemistry, Veer Narmad South Gujarat University Surat, Gujarat, India.
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A series of 4,4?-Methylene bis (N-substituted benzylidene-2-methyl-5-nitro aniline) derivatives ( Schiff bases ) Sa1 to Sa10 were prepared by the condensation of 4 4?- methylene bis(2-methyl-5-nitro aniline) with different aromatic aldehyde. Treatment of Sa1 to Sa10 with thioglycolic acid led to the formation of thiazolidinone derivatives Sb1 to Sb10. All the synthesized compounds characterized by FTIR, 1H NMR and Elemental analysis. The antibacterial activity of these compounds was first studied in vitro by the disk diffusion assay against gram positive and gram negative bacteria. The minimum inhibition concentration (MIC) was then determined with the references of standard drug ampicillin. The antifungal activity was examined against Candida albicans and Aspergillus niger by the serial plate dilution method using fluconazole as standard.

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[Savan V. Patel, Rahul B. Tailor, Sejal M. Patel, K. C. Patel and K. D. Prajapati. (2017); SYNTHESIS AND CHARACTERIZATION OF SCHIFF BASES AND THIAZOLIDINONE DERIVATIVES AND THEIR MICROBIAL EVALUATION. Int. J. of Adv. Res. 5 (Jun). 2136-2143] (ISSN 2320-5407). www.journalijar.com

Savan V. Patel
V. S. Patel College of Arts and Science Bilimora,Gujarat, India

DOI:

Article DOI: 10.21474/IJAR01/4651      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4651

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