28Jun 2017

EFFECT OF BORIC ACID ON ALVEOLAR BONE LOSS AND ITS ASSOCIATION WITH SERUM CALCIUM, ALKALINE PHOSPHATASE IN RATS: A HISTOMORPHOMETRIC & BIOCHEMICAL STUDY.

  • Senior Lecturer, Department of Periodontics, Bapuji Dental College & Hospital, Davangere Karnataka (India).
  • Professor & Head, Department of Periodontics, Bapuji Dental College & Hospital, Davangere Karnataka (India).
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Objectives: The purpose of the present study was to evaluate the morphometric and histopathologic effects of systemic boric acid in a rat periodontitis model. It was also an intent of the present study to correlate it with the biochemical markers of bone metabolism i.e.serum calcium and alkaline phosphatase. Methods: Thirty Wistar rats were divided into three groups of ten animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the maxillary second molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and tissues were histopathologically examined to assess the differences amongst the study groups.Alveolar bone loss was measured under stereomicroscope and tissues were histopathologically examined to assess, osteoclast numbers and osteoblastic activity. Results : There was statistically highly significant amount of alveolar bone loss in the ligature group (Group II) when compared to control and the boric acid group (Group III) (p<0.001). However in boric acid group (Group III),the bone loss was decreased significantly when compared to group II (p<0.001). In biochemical analysis, the serum calcium level was decreased whereas the alkaline phosphatase level was elevated significantly in boric acid group. Histopathologically, there were decreased number of osteoclasts and increased osteoblasts in boric acid group (Group III). Conclusion: Systemic administration of boric acid prevents alveolar bone loss caused by experimental periodontitis in rats as evidenced by morphometric, histolopathologic and biochemical analyses.

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[Daya S and Dhoom S. Mehta. (2017); EFFECT OF BORIC ACID ON ALVEOLAR BONE LOSS AND ITS ASSOCIATION WITH SERUM CALCIUM, ALKALINE PHOSPHATASE IN RATS: A HISTOMORPHOMETRIC & BIOCHEMICAL STUDY. Int. J. of Adv. Res. 5 (Jun). 2076-2087] (ISSN 2320-5407). www.journalijar.com

Daya S.
Senior Lecturer, Department of Periodontics, Bapuji Dental College & Hospital, Davangere Karnataka (India)

DOI:

Article DOI: 10.21474/IJAR01/4646      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4646

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