SYNERGISTIC ACTION OF STRESS AND ALCOHOL ON THE HIPPOCAMPAL REGION OF BRAIN AND USE OF ?Centella asiatica? AS A BRAIN REJUVENATOR.

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In the modern therapeutic system most of the drugs have severe side effects. To overcome this shortcoming use of Ayurvedic drugs are been promoted. We have vast wealth of Ayurvedic, Unani and Siddha systems of medicines, recommending several plants or their extracts having curative or preventive effects against several deformities. Now a days several plants are used as diuretic, sedatives, anti-tumor, anti-ulcer, anti-stress, skin-modifiers, appetite-increaser, etc. In present study Centella asiatica, which is commonly known as ?Mandukaparni? has been used as neuro-protector against the neural degeneration with special reference to Hippocampus.?Hippocampus? is the part of brain known to carry out functions like learning, transforming information, discrimination,etc. The activity in the Hippocampus is disrupted by stress and alcohol intake, interacting directly with Hippocampal neurons. In present study Centella asiatica has been used as neuro-protector, which is commonly known as ?Mandukaparni?.Present study special emphasis has been laid to see the histo-pathology of Hippocampal sub-regions, created due to stress and alcohol intake on albino rats and efforts have been made to study neural degenerations in CA1, CA2, CA3, CA4 and Dg sub-regions of Hippocampus. Here effectiveness of drug has been shown on learning and memory and it is classified as Medhya rasayan.Our results reveal Centella asiatica as neuro-protective agent; its use with stress and alcohol showed least degeneration in different sub-regions of Hippocampus.

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[Sachin Gupta and Anuj Saxena. (2017); SYNERGISTIC ACTION OF STRESS AND ALCOHOL ON THE HIPPOCAMPAL REGION OF BRAIN AND USE OF ?Centella asiatica? AS A BRAIN REJUVENATOR. Int. J. of Adv. Res. 5 (Jun). 2266-2273] (ISSN 2320-5407). www.journalijar.com

Dr. Sachin Gupta

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Article DOI: 10.21474/IJAR01/4667      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4667

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