NEPRILYSIN LIKE PEPTIDES AND SMALL MOLECULES IN THE COMBAT AGAINST AMYLOID BETA PLAQUES OF ALZHEIMER?S DISEASE THROUGH IN-SILICO BINDING STUDIES.

Alzheimer?s Disease, being one of the most detrimental Neurodegenerative diseases, is an irreversible, progressive brain disorder with changes in nerve cells resulting in their death and furthermore leading to the loss of intellectual and cognitive abilities. Despite the commercial availability of few drugs, Alzheimer?s disease is the sixth leading causes of death globally and the major public health concern, owing to a constraining coercion for action against it. For the same, many drug targets were identified among which the most potential one is the amyloid beta protein which contributes to the pathological lesions of Alzheimer?s disease, the Amyloid Beta Plaques or Senile Plaques. In the present study, two approaches ? one approach plying Neprilysin like peptides and the other approach employing a set of Small molecules, were used to target these pathological lesions with the help of Bioinformatics tools such as Discovery Studio and designed therapeutic molecules that can potentially combat against these plaques and reduce their content in neurons which might result in an improved communication and thereby enhancing the condition of the diseased person.