21Jun 2017

DOCKING OF POLYKETIDE SYNTHASE FROM PGPR2 AGAINST SELECTED TARGETS FROM PHYTOPATHOGENS.

  • Assistant Professor, Department of Biotechnology, Mother Teresa Women?s University, Kodaikanal.
  • Head, Department of Biotechnology, Mother Teresa Women?s University, Kodaikanal.
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Pseudomonads possess many traits that make them well suited as biocontrol and growth-promoting agents. PGPR influences plant growth either by direct or indirect mechanism. One of the most effective mechanisms that Plant Growth Promoting Rhizobacteria employs to prevent proliferation of phytopathogens is the synthesis of antibiotics. A wide range of different antibiotics synthesized is the PGPR trait and their specificity and mode of action have been studied it detail and only some of these strains have been commercialized. Among the various groups of antibiotics produced by the PGPR, the polyketides such as 2,4 Diacetyl phloroglucinol, Pyoluteorin and Mupirocin are highly effective in suppression of plant pathogens. In this present study, a strain isolated from rhizoshpere was found that Polyketides 3, 4-dihydroxy-N-methyl-4-(4-oxochroman-2-yl) butanamide, a novel secondary metabolite synthesised by the strain PGPR2 showed antagonism against various phytopathogens. Comparative analyses of bacterial genomes associated with fungal viability and virulence has led to the identification of many putative targets for novel antifungal agents. Genetic determinants that could contribute its plant growth promotion and biocontrol abilities have been identified by whole genome sequencing and comparative analyses with other strains of P. aeruginosa. Whole genome analysis further enhances our ability to study the secondary metabolite production and its regulation in this rhizosphere bacterial strain.

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[Illakkiam D and Usha Raja Nanthini A. (2017); DOCKING OF POLYKETIDE SYNTHASE FROM PGPR2 AGAINST SELECTED TARGETS FROM PHYTOPATHOGENS. Int. J. of Adv. Res. 5 (Jun). 1377-1386] (ISSN 2320-5407). www.journalijar.com

Illakkiam Devaraj
Mother Teresa Women's University, Kodaikanal

DOI:

Article DOI: 10.21474/IJAR01/4547      
DOI URL: https://dx.doi.org/10.21474/IJAR01/4547

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