Vol. 5 (07) pp. 836-842 DOI: 10.21474/IJAR01/4787

ENCAPSULATION OF VENLAFAXINE HCL IN TO POLY-E-CAPROLACTONE MICROSPHERES BY W/O/W AMD W/O/O EMULSION SOLVENT EVAPORATION TECHNIQUE AND COMPARISON FOR ITS CONTROLLED RELEASE PROPERTIES.

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  • M. Pharm., Department of Pharmaceutics, Girijananda Institute of Pharmaceutical Sciences, Azara, Guwahati, Assam-781017, India.
  • Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati-781017, India.
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Abstract

Objective: The objective of the proposed work was to investigate the method for the efficient encapsulation of highly water soluble venlafaxine hydrochloride into poly-e-caprolactone microspheres by water-in-oil-in-oil and water-in-oil-in water double emulsification technique and comparison for its controlled release properties. Method: The Venlafaxine loaded microspheres are prepared by water-in-oil-in-oil (w/o/w) and water-in-oil-in water (w/o/o) double emulsification technique. The compatibility study of drug with polymer was performed by Differential scanning caloriemetry (DSC) and Fourier transform infrared spectroscopy (FT-IR). The prepared microspheres are studied for their particle size, drug entrapment efficiency. The microspheres are characterised by SEM and in-vitro release of Venlafaxine was studied in phosphate buffer pH 1.2 for 12 hours and further studied for kinetic modeling. Result: The precentage yield of Venlafaxine loaded microspheres of all the formulations were found better by w/o/w method(92.21% for F 3). The particle size was found in a range of 130-135 μm and 120-125 μm for both W/O/W and W/O/O formulations. The entrapment efficiency was found in F 5 formulation prepared by W/O/O method. While the in-vitro release of Venlafaxine showed a drug release below 60% after 12 h of study whereas the marketed formulation released above 90% within 6 h and the mechanism was found to be fickian type. Conclusion: The prepared poly-ε-caprolactone microsphere is capable of delivering Venlafaxine HCl over prolonged periods, making it a potential candidate for controlled drug delivery.

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How to Cite This Article

Manabendra Rabha and Bipul Nath. (2017); ENCAPSULATION OF VENLAFAXINE HCL IN TO POLY-E-CAPROLACTONE MICROSPHERES BY W/O/W AMD W/O/O EMULSION SOLVENT EVAPORATION TECHNIQUE AND COMPARISON FOR ITS CONTROLLED RELEASE PROPERTIES., Int. J. of Adv. Res., 5 (07), 836-842, ISSN 2320-5407. DOI: https://doi.org/10.21474/IJAR01/4787

Corresponding Author

Manabendra Rabha
Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati-781017, India
Creative Commons Attribution 4.0 This work is licensed under a Creative Commons Attribution 4.0 International License.