Design of continuous fixed bed column for adsorption of Bovine Serum Albumin on nanostructured alumina based on Batch adsorption studies

This paper presents the design of fixed bed adsorption column based on the adsorption of Bovine Serum Albumin (BSA) protein on nanostructured alumina by conducting batch adsorption and continuous adsorption studies. The obtained experimental data is used to fit the Freundlich mathematical model, on the basis of results obtained from batch adsorption studies continuous column studies were carried out using a trial experimental packed column to a known bed height with nanostructured alumina as bioadsorbent. The adsorption zone height, overall mass transfer coefficient, residence time and number of mass transfer units has been determined from column studies based on the breakthrough curve.