Facial Synthesis of Some New Pyrazolopyridine, Barbituric and Thiobarbituric Acid Derivatives with Antimicrobial Activities

2-amino-3-cyanopyridine derivatives were synthesized by treating cyclic compounds containing active methylene group with arylidenemalononitrile in the presence of ammonium acetate. The behavior of 2-amino-3-cyanopyridine derivatives toward some electrophiles as triethylorthoformate followed by nitrogenious nucleophiles as hydrazine was reported; also, its reactivity toward phenyl isocyanates, thiourea, formic acid and formamide was investigated, with the aim of obtaining some interesting non-mixed heterocyclic compounds. In addition the antimicrobial activity of some selected derivatives was reported.